52266-12-3

Basic information

• Product Name: 2-methyl-3,5-diphenyl-2,3-dihydro-1,2-oxazole
• Synonyms: 2-methyl-3,5-diphenyl-2,3-dihydro-1,2-oxazole
• CAS NO: 52266-12-3
• Molecular Weight: 237.301
• Mol File: 52266-12-3.mol

Chemical Properties

• CAS DataBase Reference: 2-methyl-3,5-diphenyl-2,3-dihydro-1,2-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3,5-diphenyl-2,3-dihydro-1,2-oxazole(52266-12-3)
• EPA Substance Registry System: 2-methyl-3,5-diphenyl-2,3-dihydro-1,2-oxazole(52266-12-3)

Safety Data

• Hazardous Substances Data: 52266-12-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 3376-23-6 N-methyl-α-phenylnitrone 
• 536-74-3 phenylacetylene 
• 85311-12-2 2-methyl-3,5-diphenyl-isoxazolium; methyl sulfate 
• 16002-63-4 phenylmagnesium iodide 

Downstream Products

• 1145-01-3 3,5-Diphenylpyrazole 
• 102537-10-0 dimethyl 2-benzoyl-1-methyl-5-phenylpyrrole-3,4-dicarboxylate 

Relevant articles and documents

Synthetic method of polysubstituted 2,3-dihydroisoxazole compounds

The invention provides a synthetic method of polysubstituted 2,3-dihydroisoxazole compounds. According to the synthetic method, the polysubstituted 2,3-dihydroisoxazole compounds are synthesized from alkyne compounds and substituted nitrone under mild con

Zinc Iodide-Mediated Direct Synthesis of 2,3-Dihydroisoxazoles from Alkynes and Nitrones

A zinc diiodide (ZnI2)-mediated direct synthesis of 2,3-dihydroisoxazoles via a [3+2] cycloaddition reaction of the nitrones and non-electron-deficient terminal alkynes has been developed. This method was applied in the formal synthesis of HPA-12 and aminoglucose.

One-pot oxidation and rearrangement of propargylamines and in situ pyrazole synthesis

Reported here are procedures for a one-pot oxidation and rearrangement of propargylamines to synthesize enaminones, with supporting mechanistic studies. Also reported are the extended one-pot syntheses of pyrazoles, including celecoxib and various heterocyclic compounds.