5228-51-3

Basic information

• Product Name: 1-Ethyl-5-nitro-1H-indazole
• Synonyms: 1-Ethyl-5-nitro-1H-indazole
• CAS NO: 5228-51-3
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.18666
• EINECS: -0
• Mol File: 5228-51-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 155-157 °C
• Boiling Point: 340.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: -0.69±0.30(Predicted)
• CAS DataBase Reference: 1-Ethyl-5-nitro-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Ethyl-5-nitro-1H-indazole(5228-51-3)
• EPA Substance Registry System: 1-Ethyl-5-nitro-1H-indazole(5228-51-3)

Safety Data

• Hazardous Substances Data: 5228-51-3(Hazardous Substances Data)

Usage

General Description

1-Ethyl-5-nitro-1H-indazole is a chemical compound that belongs to the family of indazoles. It is a yellow to orange crystalline solid with a molecular formula of C9H9N3O2. 1-Ethyl-5-nitro-1H-indazole is often used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential antibacterial and antifungal properties. Additionally, 1-Ethyl-5-nitro-1H-indazole has been investigated for its potential use in the development of new materials and as a reagent in organic chemistry reactions. Overall, this chemical compound has attracted attention for its diverse pharmacological and synthetic applications.

Upstream product

• 74-96-4 ethyl bromide 
• 5401-94-5 5-nitroindazole 
• 75-03-6 ethyl iodide 

Downstream Products

• 511249-17-5 5-amino-1-ethyl-1H-indazole 

Relevant articles and documents

Synthesis, Antiviral, Antibacterial, and Cytotoxicity Assessment of Some 3H-Benzo[a]imidazo[4,5-j]acridines and 3H-Benzo[a]pyrazolo[3,4-j]acridines

Abstract: Some novel 3H-benzo[a]imidazo[4,5-j]acridines and 3H-benzo[a]pyrazolo[3,4-j]acridines were synthesized by the reaction of 1-alkyl-5-nitro-1H-benzoimidazoles and 1-alkyl-5-nitro-1H-indazoles with 1-naphthylacetonitrile in high yields. The structures of the new compounds were determined by spectral (FTIR, 1H, and 13C NMR) and analytical data. The antiviral activity of the synthesized compounds was tested against a panel of DNA and RNA viruses, including herpes simplex virus-1 KOS, vesicular stomatitis virus, herpes simplex virus-2 (G), vaccinia virus, and herpes simplex virus-1 TK-KOS ACVr. Most of the test compounds showed moderate activities in comparison with their corresponding reference standards. The synthesized compounds were also tested for antibacterial activity against a panel of strains of gram-negative and gram-positive bacterial species, and some of them we found as effective against gram- positive bacteria as well-known antibacterial agents, such as Cephalexin. The products we found to be cytostatic in the higher micromolar range.

TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE

The present invention relates to triazolo pyridines of formula (II) and their use as modulators of ?-secretase. In particular, the present invention relates to compounds which interfere with ?-secretase and/or its substrate and therefore modulate the form

Synthesis, characterisation, optical properties and theoretical calculations of a new fluorescent heterocyclic system: 3H-benzo[a]pyrazolo[3,4-j]acridine

Four new fluorescent dyes derived from the 3H-benzo[a]pyrazolo[3,4-j]acridine system were synthesised and fully characterised by 1H NMR, 13C NMR, mass and analytical data. These new fluorophores were prepared from the reaction of 1-alkyl-5-nitro-1H-indazoles with 1-naphthylacetonitrile via nucleophilic substitution of hydrogen, in high yields. The optical properties of the dyes were also investigated and the results revealed that, in some cases, they have higher quantum yields compared with well-known fluorescent dyes such as fluorescein. Solvent effects on the fluorescence characteristics of the four compounds indicated that the emission wavelength is red-shifted with increasing solvent polarity. Furthermore, density functional theory calculations using the B3LYP hybrid functional and the 6-311++G(d,p) basis set provided the optimised geometries and relevant frontier orbitals of the compounds. Calculated electronic absorption spectra were also obtained using the time-dependent density functional theory method.