52281-05-7

Basic information

• Product Name: (3Z)-3-[(phenylamino)methylidene]-2H-chromene-2,4(3H)-dione
• CAS NO: 52281-05-7
• Molecular Formula: C₁₆H₁₁NO₃
• Molecular Weight: 265.2634
• Mol File: 52281-05-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 438.5°C at 760 mmHg
• Flash Point: 219°C
• Density: 1.434g/cm³
• Vapor Pressure: 6.9E-08mmHg at 25°C
• Refractive Index: 1.755
• CAS DataBase Reference: (3Z)-3-[(phenylamino)methylidene]-2H-chromene-2,4(3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3Z)-3-[(phenylamino)methylidene]-2H-chromene-2,4(3H)-dione(52281-05-7)
• EPA Substance Registry System: (3Z)-3-[(phenylamino)methylidene]-2H-chromene-2,4(3H)-dione(52281-05-7)

Safety Data

• Hazardous Substances Data: 52281-05-7(Hazardous Substances Data)

Usage

Description

(3Z)-3-[(phenylamino)methylidene]-2H-chromene-2,4(3H)-dione, also known as PAMD, is a chemical compound belonging to the class of organic compounds known as chromones. These compounds are found in plants and have been studied for their anti-inflammatory and antioxidant properties. PAMD has a unique structure that includes a chromene ring with a phenylamino group and a methylidene group, which contribute to its biological activity. It has been the subject of research for its potential as an anti-cancer agent, as it has been shown to inhibit the growth of cancer cells in vitro.

Uses

Used in Pharmaceutical Industry:
PAMD is used as a potential anti-cancer agent for its ability to inhibit the growth of cancer cells in vitro. Its unique structure and biological activity make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Research and Development:
PAMD is used in research and development for its potential therapeutic applications. Further studies are needed to fully understand the potential benefits and mechanisms of action of this compound, which could lead to the development of new treatments for various diseases and conditions.

Upstream product

• 39079-62-4 chromone-3-carboxylic acid 
• 62-53-3 aniline 
• 1535170-91-2 4-chloro-3-dichloromethyl-2-(N-phenyl)imino-2H-1-benzopyran 
• 213273-03-1 4-oxo-2-(N-phenyl)amino-4H-chromene-3-carbaldehyde 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 113326-75-3 N-((4-oxo-4H-chromen-3-yl)methylene)aniline oxide 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 122-51-0 orthoformic acid triethyl ester 
• 100-63-0 phenylhydrazine 
• 73754-71-9 3-Ureidomethylen-<2H,4H>-benzopyran-2,4-dion 

Downstream Products

• 154417-86-4 4-anilino-3-formyl-2(2H)-chromenone 
• 74798-88-2 3-Benzenesulfonyl-pyrano[3,2-c]chromene-2,5-dione 
• 74813-16-4 3-Phenyl-pyrano[3,2-c]chromene-2,5-dione 

Relevant articles and documents

Contributions to the Chemistry of Enaminoketones, XV: The Three-Component Synthesis of Hydrazinomethylene-chromandiones and a reductive N-N Bond Cleavage of Phenylhydrazine

The three-component reaction of 4-hydroxycoumarin, ethylorthoformiate, and different substituted hydrazines is described. p-Nitrophenylhydrazine, hydrazides and phenylsemicarbazide lead to the expected hydrazinomethylene-chromandiones 2a-f.Reaction of 4-hydroxycoumarin, ethylorthoformiate, and phenylhydrazine or p-tolyl-hydrazine does not yield 2, but the anilino-methylene-chromandiones 6a-b.This indicates a reductive N-N bond cleavage to aniline and ammonia under mild conditions. - Keywords: Hydrazinomethylene-chromandiones; Reductive N-N bond cleavage; Anilinomethylenechromandiones

POCl3-mediated synthesis of 2-N-arylimino-4-chloro-3- dichloromethylcoumarin and its conversion into 6H-[1]benzopyrano[4,3-b]quinolin- 6-one

On heating in POCl3, 2-(N-aryl)aminochromone-3-carbaldehyde produced 2-N-arylimino-4-chloro-3-dichloromethylcoumarin, which undergoes selective acid-catalyzed hydrolysis of its imino function to produce 4-chioro-3-dichloromethylcoumarin. The hy

Reaction of Amines on 3-Ureidomethylenecoumarins. A New Route to N-(Methylene-4-oxocoumarinyl)amines

N-(Methylene-4-oxocoumarinyl)amines were prepared in good yield by reacting aliphatic and aromatic amines bearing functional groups with the relevant 3-ureidomethylenecoumarins.