52281-05-7

Usage

Uses

Used in Pharmaceutical Industry:
PAMD is used as a potential anti-cancer agent for its ability to inhibit the growth of cancer cells in vitro. Its unique structure and biological activity make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Research and Development:
PAMD is used in research and development for its potential therapeutic applications. Further studies are needed to fully understand the potential benefits and mechanisms of action of (3Z)-3-[(phenylamino)methylidene]-2H-chromene-2,4(3H)-dione, which could lead to the development of new treatments for various diseases and conditions.

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 122-51-0 orthoformic acid triethyl ester 
• 62-53-3 aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 113326-75-3 N-((4-oxo-4H-chromen-3-yl)methylene)aniline oxide 
• 39079-62-4 chromone-3-carboxylic acid 
• 1535170-91-2 4-chloro-3-dichloromethyl-2-(N-phenyl)imino-2H-1-benzopyran 
• 213273-03-1 4-oxo-2-(N-phenyl)amino-4H-chromene-3-carbaldehyde 
• 100-63-0 phenylhydrazine 
• 73754-71-9 3-Ureidomethylen-<2H,4H>-benzopyran-2,4-dion 

Downstream Products

• 74813-16-4 3-Phenyl-pyrano[3,2-c]chromene-2,5-dione 
• 74798-88-2 3-Benzenesulfonyl-pyrano[3,2-c]chromene-2,5-dione 
• 154417-86-4 4-anilino-3-formyl-2(2H)-chromenone 

Relevant academic research and scientific papers

Contributions to the Chemistry of Enaminoketones, XV: The Three-Component Synthesis of Hydrazinomethylene-chromandiones and a reductive N-N Bond Cleavage of Phenylhydrazine

The three-component reaction of 4-hydroxycoumarin, ethylorthoformiate, and different substituted hydrazines is described. p-Nitrophenylhydrazine, hydrazides and phenylsemicarbazide lead to the expected hydrazinomethylene-chromandiones 2a-f.Reaction of 4-hydroxycoumarin, ethylorthoformiate, and phenylhydrazine or p-tolyl-hydrazine does not yield 2, but the anilino-methylene-chromandiones 6a-b.This indicates a reductive N-N bond cleavage to aniline and ammonia under mild conditions. - Keywords: Hydrazinomethylene-chromandiones; Reductive N-N bond cleavage; Anilinomethylenechromandiones

Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of poten

POCl3-mediated synthesis of 2-N-arylimino-4-chloro-3- dichloromethylcoumarin and its conversion into 6H-[1]benzopyrano[4,3-b]quinolin- 6-one

On heating in POCl3, 2-(N-aryl)aminochromone-3-carbaldehyde produced 2-N-arylimino-4-chloro-3-dichloromethylcoumarin, which undergoes selective acid-catalyzed hydrolysis of its imino function to produce 4-chioro-3-dichloromethylcoumarin. The hy

Exploring α-chromonyl nitrones as 1,5-dipoles

N-Phenyl-C-chromonyl nitrones 1 and the allenoate zwitterion 2, generated by addition of phosphine to acetylenedicarboxylates, undergo a cascade reaction sequence involving an unprecedented [5+3] annulation followed by deoxygenative rearrangement leading to dihydropyridine-fused benzopyrones. Unusual electronic control by the N-substituents of 1 directs the annulation pathway, leading to two different ring-systems. Georg Thieme Verlag Stuttgart - New York.

Reaction of Amines on 3-Ureidomethylenecoumarins. A New Route to N-(Methylene-4-oxocoumarinyl)amines

N-(Methylene-4-oxocoumarinyl)amines were prepared in good yield by reacting aliphatic and aromatic amines bearing functional groups with the relevant 3-ureidomethylenecoumarins.