52288-44-5

Upstream product

• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 5470-91-7 m-methoxychalcone 
• 98-86-2 acetophenone 
• 591-31-1 3-methoxy-benzaldehyde 
• 5470-91-7 3-methoxy-chalcone 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 1345732-73-1 C₁₆H₁₃ClO₂ 
• 1431527-01-3 C₂₅H₂₁ClO₄ 
• 1431527-14-8 C₁₆H₁₅ClO₃ 
• 1431526-83-8 3-chloro-3-(m-methoxyphenyl)-1-phenylpropane-1,2-dione 

Relevant academic research and scientific papers

Darzens reaction promoted by KF/alumina: A novel stereoselective method for rapid and efficient synthesis of trans-α,β-epoxy ketones

The Darzens condensation of α-chloroacetophenone with various aromatic aldehydes mediated by potassium fluoride on alumina at room temperature resulted in formation of good to excellent yields of trans-α,β-epoxy ketones in short time periods. Copyright Ta

Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst

Asymmetric synthesis with cheaper and non-toxic alkaline earth metal catalysts is becoming an important and sustainable alternative to conventional catalytic methodologies mostly relying on precious metals. In spite of some sustainable methods for enantioselective epoxidation of enones, the development of a well-defined and efficient catalyst based on magnesium complexes for these reactions is still a challenging task. In this perspective, we present the application of chiral dinuclear magnesium complexes for asymmetric epoxidation of a broad range of electron-deficient enones. We demonstrate that the in situ generated magnesium-ProPhenol complex affords enantioenriched oxiranes in high yields and with excellent enantioselectivities (up to 99% ee). Our extensive study verifies the literature data in this area and provides a step forward to better understand the factors controlling the oxygenation process. Elaborated catalyst offers mild reaction conditions and a truly wide substrate scope. (Figure presented.).

Visible Light-Induced Aerobic Epoxidation of α,β-Unsaturated Ketones Mediated by Amidines

An aerobic photoepoxidation of α,β-unsaturated ketones driven by visible light in the presence of tetramethylguanidine (3b), tetraphenylporphine (H2TPP), and molecular oxygen under mild conditions was revealed. The corresponding α,β-epoxy ketones were obtained in yields of up to 94% in 96 h. The reaction time was shortened to 4.6 h by flow synthesis. The mechanism related to singlet oxygen was supported by experiments and density functional theory (DFT) calculations.

Method for preparing epoxide through induction of visible light

The invention belongs to the technical field of organic synthesis and provides a method for preparing an epoxide through induction of visible light. The method comprises the following step: under thecondition that the visible light and a photosensitizer exist, by taking oxygen or air as an oxygen source or an oxidizing agent and taking a synthesized amidine derivative as a catalyst, performing areaction at the temperature of -40-50 DEG C for 36h-192h, so that olefin is directly oxidized into the corresponding epoxide. The method is mild in reaction conditions, and the yield is as high as 94%or above, therefore, the method has good development value and application prospect.

Photochemistry of Aromatic α,β-Epoxy Ketones. Substituent Effects on Oxirane Ring-Opening and Related Ylide Behavior

Upon 337.1-nm laser excitation, chalcone epoxides containing donor/acceptor substituents at para positions of phenyl and benzoyl groups undergo triplet-mediated ring opening to carbonyl ylides observable by broad absorption spectra (λmaxY=520-600 nm, εmaxY (13-27) x 103 M-1 cm-1 in benzene) on a microsecond time scale (τY=0.4-24 μs in benzene).The short-lived, carbonyl-type triplets (τT=0.8-100 ns) giving rise to ylides are monitored in some cases by direct transient absorption on a nanosecond time scale and, for all systems, are probed by quenching studies with 1-methylnaphthalene and 2,5-dimethyl-2,4-hexadiene.Substituent effects on ylide absorption maxima, ylide decay kinetics, reactivity toward dipolarophiles and methanol, and precursor triplet lifetimes are discussed in the light of charge delocalization in dipolar structures, variation in HOMO/LUMO energies, complexity of thermal processes contributing to ylide decay, and energy gap between an ylide triplet and its triplet carbonyl precursor (ring closed).