52311-60-1Relevant articles and documents
Process for preparing 8-hydroxyclomipramine or its pharmaceutically acceptable salt
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Paragraph 0060-0062, (2016/10/10)
Provided are a method for synthesizing a novel intermediate, namely, 3-(3-chloro-8-methoxy-10,11-dehydro-5H-dibenzo[b,f]Azepine-5-yl)-N,N-dimethylpropan-1-amine or 8-hydroxyclomipramine using a salt thereof, or a pharmaceutically acceptable salt thereof,
Lewis acid-mediated Michaelis-Arbuzov reaction at room temperature: A facile preparation of arylmethyl/heteroarylmethyl phosphonates
Rajeshwaran, Ganesan Gobi,Nandakumar, Meganathan,Sureshbabu, Radhakrishnan,Mohanakrishnan, Arasambattu K
supporting information; experimental part, p. 1270 - 1273 (2011/04/23)
A facile preparation of arylmethyl and heteroarylmethyl phosphonate esters was achieved involving a Lewis acid mediated Michaelis-Arbuzov reaction at room temperature. Interaction of arylmethyl halides/alcohols with triethyl phosphite in the presence of Lewis acid at room temperature afforded phosphonate esters in good yields.
Preparation of asymmetric iminodibenzyl compounds
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, (2008/06/13)
Iminodibenzyl derivatives of the formula: SPC1 Wherein R and R1 each represent hydrogen, halogen, amino, sulfamoyl, lower alkyl, lower alkoxy or lower alkanoyl, provided that R and R1 can not both be hydrogen and when R and R1 are the same, they are located at positions asymmetric to each other, are produced in high purity and yield by a series of reactions which proceed through novel 2,2'-dinitrostilbene or 2,2'-diaminostilbene and 2,2'-diaminodibenzyl derivatives. The reaction sequence involves condensation, reduction and ring-closure reactions to give asymmetric as well as symmetric iminodibenzyl derivatives. The resulting iminodibenzyl derivatives may be converted to useful pharmaceutical compounds having anti-depressant, analgesic or anti-allergic properties.
