52333-36-5

Upstream product

• 1232-99-1 2,3-diphenylpyrido[3,2-b]pyrazine 
• 452-58-4 2,3-Diaminopyridine 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 134-81-6 benzil 

Downstream Products

• 1356332-87-0 7-(2,3-diphenyl-7,8-dihydropyrido[3,2-b]pyrazin-5(6H)-yl)heptanoic acid ethyl ester 
• 1356333-05-5 5-(pent-4-enyl)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[3,2-b]pyrazine 
• 1356332-93-8 ethyl 7-(8-ethyl-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate 
• 1356332-61-0 8-ethyl-2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine 
• 1356331-92-4 7-(8-ethyl-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid 
• 1356331-61-7 7-(2,3-diphenyl-7,8-dihydropyrido[3,2-b]pyrazin-5(6H)-yl)heptanoic acid 
• 1356332-74-5 rac-5-(tert-butoxycarbonyl)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[2,3-b]pyrazine-7,8-diyl diacetate 
• 1356332-73-4 rac-tert-butyl 7,8-dihydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate 
• 1356332-72-3 tert-butyl 2,3-diphenylpyrido[2,3-b]pyrazine-5(6H)-carboxylate 
• 1356332-70-1 tert-butyl 8-(dimethylamino)-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate 
• 1356332-63-2 tert-butyl 8-methoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate 
• 1356332-59-6 (R)-tert-butyl 8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate 
• 1356332-60-9 (S)-tert-butyl 8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate 
• 1356332-56-3 tert-butyl 8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate 

Relevant academic research and scientific papers

Ip receptor agonist heterocyclic compounds

The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various or

An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives

A ruthenium-catalysed annulative transfer hydrogenation strategy, enabling straightforward access to tetrahydro fused-pyrazine derivatives from N-heteroaryl diamines and vicinal diols, has been demonstrated for the first time. Such a synthesis proceeds with unprecedented synthetic effectiveness including high step- and atom efficiency, generation of water as the sole by-product, short reaction time and no need for external high pressure H2 gas, offering an important basis for the transformation of vicinal diols, a class of bio-mass derived resources, into functionalized products.

IP RECEPTOR AGONIST HETEROCYCLIC COMPOUNDS

The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.

Regioselectivite de l'hydrogenation catalitique de quelques pyridopyrazines

Catalytic hydrogenation on palladium-carbon in ethanol of several pyridopyrazines leads to mixtures of the 1,2,3,4- and 5,6,7,8-tetrahydro derivatives except in two cases: the reduction of the nonsubstituted heterocycle takes place on the pyrazine