diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine

Base Information

• Chemical Name: diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine
• CAS No.: 52333-36-5
• Molecular Formula: C₁₉H₁₇N₃
• Molecular Weight: 287.364
• Mol file: 52333-36-5.mol

Synonyms:diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine

Chemical Property of diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine

There total 6 articles about diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3-diphenylpyrido[3,2-b]pyrazine (1232-99-1) → diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine (52333-36-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 24h;

DOI:10.1139/v82-400

Reference yield: 71.0%

2,3-Diaminopyridine (452-58-4) + 1,2-diphenyl-1,2-ethanediol (492-70-6,655-48-1,2325-10-2,38270-73-4,52340-78-0,579-43-1) → diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine (52333-36-5)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tert-Amyl alcohol; at 130 ℃; for 5h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1039/c6cc05329g

Reference yield:

2,3-Diaminopyridine (452-58-4) → diphenyl-2,3 tetrahydro-5,6,7,8 pyrido<2,3-b>pyrazine (52333-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.17 h / 160 °C / microwave irradiation

2: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 61 h / 20 °C / 75.01 Torr

With hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran;

upstream raw materials:

2,3-diphenylpyrido[3,2-b]pyrazine

2,3-Diaminopyridine

benzil

1,2-diphenyl-1,2-ethanediol

Downstream raw materials:

7-(2,3-diphenyl-7,8-dihydropyrido[3,2-b]pyrazin-5(6H)-yl)heptanoic acid ethyl ester

5-(pent-4-enyl)-2,3-diphenyl-5,6,7,8-tetrahydropyrido[3,2-b]pyrazine

7‐(acetyloxy)‐2,3‐diphenyl‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

(R)-7-(8-hydroxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid