52333-96-7

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 610-14-0 2-nitrobenzyl chloride 
• 1028-86-0 N-(2-chloro-pyridin-3-yl)-2-nitro-benzamide 
• 52334-59-5 3-(2-nitro-benzoylamino)-1H-pyridin-2-one 

Downstream Products

• 52334-23-3 N-(2-oxazolo[5,4-b]pyridin-2-yl-phenyl)-benzamide 
• 52334-22-2 2-oxazolo[5,4-b]pyridin-2-yl-aniline 

Relevant academic research and scientific papers

2-(Nitroaryl)benzothiazole and benzoxazole derivatives as fluorogenic substrates for the detection of nitroreductase activity in clinically important microorganisms

A series of carboxy-substituted 2-(nitroaryl)benzothiazole derivatives and carboxy-substituted 2-(nitroaryl)benzoxazole derivatives were prepared and evaluated as potential nitroreductase substrates for the purpose of detecting clinically important microorganisms. Several of the substrates produced highly fluorescent colonies with the majority of a panel of 10 Gram-negative bacteria and also with two of a panel of 8 Gram-positive bacteria.

Process for the synthesis of oxazolopyridine compounds

Process for the synthesis of compounds of formula (I): STR1 their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; R1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; 0≤m≤2; R2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group STR2 such that: R3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, 0≤n≤5 employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.

A New Convenient Synthesis of 2-Aryl- and 2-Heteroaryloxazolopyridines

Several 2-aryl- and 2-heteroaryloxazolopyridines were synthesized in high yields from 3-(arylcarbonylamino)-2-chloropyridines by heating in the presence of trimethylsilylpolyphosphate ester.

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.