52334-72-2

Upstream product

• 84446-21-9 3-(2'-chlorobenzoyl)amino-2-chloropyridine 
• 6298-19-7 2-chloro-3-aminopyridine 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 52334-10-8 2-(2-chloro-phenyl)oxazolo<5,4-b>pyridine 
• 88369-28-2 3-(2'-chlorobenzoyl)aminothiopyrid-2-one 
• 88369-29-3 2-(2'-chlorophenyl)thiazolo<5,4-b>pyridine 

Relevant academic research and scientific papers

Novel synthesis of 5,11-dihydro-6H-pyrido[2,3-b]-[1,4]-benzodiazepin-6-ones and related studies (1)

5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (1), a basic intermediate in the preparation of 11-α-aminoacetyl derivatives with important biological activities, has been obtained by a three-step synthesis starting from easily available isatoic anhydride and anhydro ornithine. Some model cyclisation reactions leading to 5-member ring derivatives 10 and 12 instead of 7-member ring analogues of 1, are reported. Easy transformations of the tetrahydro congener of 1, i.e. compound 4 into 19, which actually represents a tetrahedral intermediate in the transformation of 5 into 4, is noticed. Further rearrangement of 19 into spiro compounds 20, and return of the latter into 5 is described.

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.