5234-86-6 Usage
Originator
Azaquinzole,Onbio Inc.
Manufacturing Process
2 Methods of producing of 1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-
a]isoquinoline:
1). 214.0 g diethyl ester of oxalic acid are mixed with a solution of 238.0 g 1-
aminomethyl-1,2,3,4-tetrahydroisoquinoline in 200 ml alcohol are boiled for 7
h. After cooling, the obtained crystals of 1,2,3,6,7,11b-hexahydro-4Hpyrazino[
2,1-a]isoquinoline-3,4-dione are vacuum-filtered and washed with
acetone and dried, melting point 220°C. Yield: 240.0 g.
55.0 g lithium aluminum hydride are dissolved in 650 ml absolute
tetrahydrofuran and mixed dropwise with a suspension of 120.0 g
1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline-3,4-dione in 300 ml
absolute tetrahydrofuran. After 7 h of boiling, the residual hydride is
decomposed by the addition of water, and the reaction solution is worked up.
The obtained 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is
distilled in vacuum, boiling point 98°-100°C/0.01 mm. Yield: 86.0 g.
2). 16.2 g 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline and 18.7 g ethylene
dibromide are boiled for 4 h in n-butanol, with the addition of 13.8 g
potassium carbonate. After the solvent is evaporated, the residue is treated with water, mixed with sodium hydroxide solution, and shaken out with
chloroform. The chloroform solution is dried, concentrated by evaporation, and
the resulting 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is
distilled at 98°-100°C/0.01 mm. The yield amounts to 7.5 g.
Therapeutic Function
CNS depressant
Check Digit Verification of cas no
The CAS Registry Mumber 5234-86-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,3 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5234-86:
(6*5)+(5*2)+(4*3)+(3*4)+(2*8)+(1*6)=86
86 % 10 = 6
So 5234-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N2/c1-2-4-11-10(3-1)5-7-14-8-6-13-9-12(11)14/h1-4,12-13H,5-9H2
5234-86-6Relevant academic research and scientific papers
Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum
Wang, Wen-Long,Song, Li-Jun,Chen, Xia,Yin, Xu-Ren,Fan, Wen-Hua,Wang, Gu-Ping,Yu, Chuan-Xin,Feng, Bainian
, p. 9163 - 9178 (2013/09/23)
The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.
2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS
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Page/Page column 180, (2008/06/13)
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof (I) wherein R2 represents a hydrogen or the like; R3 represents methyl group or the like; R20 represents a halogen atom or the like; q represents an integer of 0 to 3; Z represent nitrogen atom, CH, or the like; R4 represents hydrogen or the like; R5 represents hydrogen or the like; R6 represents a substituted alkyloxy and the like; p represents an integer of 0 to 3; X represents bond, CH2, oxygen atom, NH, or the like; any one or more of R5 and R6, R5 and R4, R6 and R4, X and R5, X and R4, X and R6, and R6 and R6 may combine to each other to form a ring, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).
