52358-22-2

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

This is the commonly used name for the compound, which is derived from its structural features.

Explanation

The compound is in a liquid state and has a yellowish color.

Explanation

The compound has a strong, pungent smell.

Explanation

The compound is used in various industries due to its versatile chemical properties.

Explanation

The compound is highly flammable, which means it can easily catch fire and burn.

Explanation

Due to its flammable nature, it is important to take necessary safety measures when using 1(2H)-Pyridinecarboxylicacid,2-methyl-,methylester(9CI) in industrial settings.

Physical State

Yellowish liquid

Odor

Pungent

Applications

Pharmaceutical production, agricultural chemicals, organic synthesis, flavoring agent, and intermediate for other chemical syntheses

Flammability

Flammable

Safety Precaution

Handle with care in industrial processes

Upstream product

• 110-86-1 pyridine 
• 917-64-6 methyl magnesium iodide 
• 79-22-1 methyl chloroformate 
• 75-16-1 methylmagnesium bromide 
• 86950-96-1 1-(methoxycarbonyl)pyridine-1-ium chloride 
• 78999-63-0 α-methyl-piperidine 
• 114523-66-9 3-Bromo-2-methoxy-6-methyl-piperidine-1-carboxylic acid methyl ester 
• 82483-58-7 2-Methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 114523-70-5 6-Methoxy-2-methyl-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester 

Downstream Products

• 96384-93-9 6-Methyl-2-phenyl-3-oxa-2,5-diaza-bicyclo[2.2.2]oct-7-ene-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Highly Regioselective α-Addition of Alkynyl and Alkenyl Grignard Reagents to 1-Alkoxycarbonylpyridinium Salts and Its Application to Synthesis of 1-Azabicycloalkanes and (+/-)-Solenopsin A

Nucleophilic addition of a variety of alkynyl and alkenyl Grignard reagents to 1-methoxycarbonylpyridinium chloride takes place at the α-position in a highly regioselective manner to give 2-substituted 1-methoxycarbonyl-1,2-dihydropyridines exclusively, while, with alkyl Grignard reagents, a lack of the regioselectivity is observed.These results may be explained by the HSAB principle.The high α-regioselectivity is preserved in the cases of 2-substituted pyridines as well, giving 2,6-disubstituted 1,2-dihydropyridines exclusively, which can be transformed stereoselectively into cis- and trans-2,6-dialkylated piperidines.These highly regioselective α-alkynylations of 1-methoxycarbonylpyridinium salts are exploited in synthesis of 1-azabicycloalkanes as well as (+/-)-solenopsin A.

A NEW METHOD FOR REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED 1-(METHOXYCARBONYL)-1,2-DIHYDROPYRIDINES

2-Substituted 1,2-dihydropyridines including an optically active one were regioselctively prepared from 2-substituted piperidines through three intermediates, that is, (a) 1,2,3,4-tetrahydropyridines, (b) 5-bromo-6-methoxypiperidines, and (c) 1,2,3,4-tetrahydro-6-methoxypyridines.

ON THE REGIOSELECTIVITY OF THE REACTION OF N-METHOXYCARBONYLPYRIDINIUM CHLORIDE WITH GRIGNARD REAGENTS: HIGHLY REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED N-METHOXYCARBONYL-1,2-DIHYDROPYRIDINES.

Whereas alkyl Grignard reagents undergo 1,2- and 1,4-additions to N-methoxycarbonyl-pyridinium chloride in a variable ratio, alkenyl and alkynyl Grignard reagents do the exclusive 1,2-addition to afford 2-substituted N-methoxycarbonyl-1,2-dihydropyridines in fair to excellent yields.

STEREOSELECTIVE SYNTHESIS OF dl-PROSAFRININE AND dl-PSEUDOCARPAMIC ACID

The SnCl2-effected carbon-carbon bond formation of endoperoxides was applied to alkyl substituted 1,2-dihydropyridines 1a-h to produce 3a-h and 4a-h, whose stereochemistry was clarified.Starting from 3e and 4e, piperidine alkaloids, prosafrinine and pseud