52372-96-0Relevant academic research and scientific papers
Microwave-accelerated reductive amination between ketones and ammonium acetate
Dong, Li,Aleem, Saadat,Fink, Cynthia A.
experimental part, p. 5210 - 5212 (2010/11/05)
A new procedure for reductive amination between ketones and ammonium acetate has been developed to access a variety of primary amines. This protocol takes advantage of microwave heating to significantly accelerate the reaction and offers a convenient and effective method to access some interesting amines. This new procedure compares favorably to previously reported approaches in terms of practicality, efficiency, and functional group compatibility.
PYRIDINONE ANTAGONISTS OF ALPHA-4 INTEGRINS
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, (2010/11/17)
The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula (I) or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2
SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
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Page/Page column 16; 17, (2008/12/04)
Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.
Multicyclic bis-amide MMP inhibitors
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Page/Page column 114, (2008/06/13)
The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.
