52386-79-5

Basic information

• Product Name: L-Cysteine, S-[(4-chlorophenyl)methyl]-
• CAS NO: 52386-79-5
• Molecular Formula: C10H12ClNO2S
• Molecular Weight: 245.73
• Mol File: 52386-79-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Cysteine, S-[(4-chlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Cysteine, S-[(4-chlorophenyl)methyl]-(52386-79-5)
• EPA Substance Registry System: L-Cysteine, S-[(4-chlorophenyl)methyl]-(52386-79-5)

Safety Data

• Hazardous Substances Data: 52386-79-5(Hazardous Substances Data)

Upstream product

• 921-01-7 rac-cysteine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 52-89-1 l-cysteine hydrochloride 
• 52-90-4 L-Cysteine 

Downstream Products

• 152684-57-6 N^α-Fmoc-S-(4-chlorobenzyl)cysteine 
• 85684-19-1 N-acetyl-S-(4-chloro-benzyl)-L-cysteine 

Relevant articles and documents

Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors

We studied synthetic modifications of N-mercaptoacylamino acid derivatives to develop a new class of leukotriene A4 (LTA4) hydrolase inhibitors. S-(4-Dimethylamino)benzyl-l-cysteine derivative 2a (SA6541) showed inhibitory activity against LTA4 hydrolase (IC50, 270 nM) and selectivity over other metallopeptidases except angiotensin-converting enzyme (ACE, IC50, 520 nM). Modification at the para-substituent of the phenyl ring of compound 2a improved LTA4 hydrolase inhibitory activity as well as selectivity over ACE. Finally, we obtained S-(4-cyclohexyl)benzy-l-cysteine derivatives 11l and 16i as potent and selective LTA4 hydrolase inhibitors.