524005-25-2

Upstream product

• 524005-23-0 5-allyl-1-benzyl-4-methoxy-1H-pyrrol-2(5H)-one 
• 149-73-5 trimethyl orthoformate 
• 524005-33-2 5-allyl-4-methoxy-1,5-dihydro-pyrrol-2-one 

Downstream Products

• 1026153-18-3 6-(3-benzyloxy-propyl)-1-aza-spiro[4.5]dec-6-en-2-one 
• 524005-26-3 5-allyl-1-benzyl-5-(1-hydroxy-but-3-enyl)-4-methoxy-1,5-dihydro-pyrrol-2-one 
• 524005-27-4 1-benzyl-10-hydroxy-4-methoxy-1-aza-spiro[4.5]deca-3,7-dien-2-one 
• 524005-34-3 2-allyl-1-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrole-2-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of the tricyclic core of the marine alkaloid lepadiformine

A stereoselective synthesis of the tricyclic core in racemic form of the marine alkaloid Lepadiformine is described from 4-methoxy-3-pyrrolin-2-one (methyl tetramate). Key steps involve 5,5-dialkylation of the tetramate, metathesis closure to an A/C 1-aza