524018-29-9

Upstream product

• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 524018-19-7 [2-(4-fluoro-phenyl)-1-(5-naphthalen-2-yl-4-oxo-tetrahydro-pyran-2-yl)-ethyl]carbamic acid tert-butyl ester 
• 524018-16-4 [2-(4-fluoro-phenyl)-1-(5-naphthalen-2-yl-4-oxo-3,4-dihydro-2H-pyran-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 524018-10-8 [1-(5-bromo-4-oxo-3,4-dihydro-2H-pyran-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 524018-08-4 [1-(4-oxo-3,4-dihydro-2H-pyran-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 32316-92-0 naphthalene-2-boronic acid 

Downstream Products

• 524018-35-7 C₄₁H₅₅FN₄O₇ 
• 524018-36-8 C₄₁H₅₅FN₄O₇ 
• 524018-32-4 [1-(4-cyanomethyl-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester 
• 524018-31-3 [1-(4-cyanomethyl-5-naphthalen-2-yl-tetrahydro-pyran-2-yl)-2-(4-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of 2,4,5-trisubstituted tetrahydropyrans as peptidomimetic scaffolds for melanocortin receptor ligands.

[reaction: see text] We have synthesized a series of 2,4,5-trisubstituted tetrahydropyran derivatives to determine the utility of this scaffold as a peptidomimetic platform. The key synthetic steps involved a palladium-mediated cross-coupling reaction of