52417-07-9

Basic information

• Product Name: 3′,5′-di-O-trityl-thymidine
• Synonyms: 3′,5′-di-O-trityl-thymidine
• CAS NO: 52417-07-9
• Molecular Weight: 726.872
• Mol File: 52417-07-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3′,5′-di-O-trityl-thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3′,5′-di-O-trityl-thymidine(52417-07-9)
• EPA Substance Registry System: 3′,5′-di-O-trityl-thymidine(52417-07-9)

Safety Data

• Hazardous Substances Data: 52417-07-9(Hazardous Substances Data)

Upstream product

• 7791-71-1 5'-O-tritylthymidine 
• 50-89-5 thymidine 
• 76-83-5 trityl chloride 
• 50591-13-4 O⁴-methyl thymidine 
• 109389-25-5 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one 

Downstream Products

• 519-73-3 triphenylmethane 
• 5333-62-0 benzyl trityl ether 
• 65-71-4 thymin 
• 50-89-5 thymidine 
• 73189-04-5 3'-O-triphenylmethylthymidine 
• 76-84-6 triphenylmethyl alcohol 

Relevant articles and documents

Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.

In search of flavivirus inhibitors: Evaluation of different tritylated nucleoside analogues

Following up on a hit that was identified in a large scale cell-based antiviral screening effort, a series of triphenylmethyl alkylated nucleoside analogues were synthesized and evaluated for their in vitro antiviral activities against the dengue virus (DENV) and the yellow fever virus (YFV). Hereto, trityl moieties were attached at various positions of the sugar ring combined with subtle variations of the heterocyclic base. Several triphenylmethyl modified nucleosides were uncovered being endowed with submicromolar in vitro antiviral activity against the YFV. The most selective inhibitor in this series was 3′,5′-bis-O-tritylated-5-chlorouridine (1b) affording a selectivity index of over 90, whereas the 3′,5′-bis-O-tritylated inosine congener (5b) displayed the highest activity, but proved more toxic. The finding of these lipophilic structures being endowed with high antiviral activity for flaviviruses, should stimulate the interest for further structureeactivity research.