109389-25-5

Basic information

• Product Name: 2(1H)-Pyrimidinone, 1-(2-deoxy-b-D-erythro-pentofuranosyl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)
• Synonyms: 2(1H)-Pyrimidinone, 1-(2-deoxy-b-D-erythro-pentofuranosyl)-5-methyl-4-(1H-1,2,4-triazol-1-yl);1-(2-deoxy-b-D-erythro-pentofuranosyl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)-2(1H)-Pyrimidinone
• CAS NO: 109389-25-5
• Molecular Formula: C₁₂H₁₅N₅O₄
• Molecular Weight: 293.2786
• Mol File: 109389-25-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 624.7°Cat760mmHg
• Flash Point: 331.6°C
• Appearance: /
• Density: 1.69g/cm³
• Vapor Pressure: 1.8E-16mmHg at 25°C
• Refractive Index: 1.754
• CAS DataBase Reference: 2(1H)-Pyrimidinone, 1-(2-deoxy-b-D-erythro-pentofuranosyl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, 1-(2-deoxy-b-D-erythro-pentofuranosyl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)(109389-25-5)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, 1-(2-deoxy-b-D-erythro-pentofuranosyl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)(109389-25-5)

Safety Data

• Hazardous Substances Data: 109389-25-5(Hazardous Substances Data)

Usage

Molecular Structure

The compound consists of a pyrimidinone ring with a 2-deoxy-b-D-erythro-pentofuranosyl-5-methyl-4-(1H-1,2,4-triazol-1-yl) substituent.

Complexity

The structure of the compound is complex, which contributes to its unique properties and potential applications.

Building Block

The compound is an important building block in the synthesis of nucleoside analogs.

Applications

The compound has potential applications in pharmaceuticals and biotechnology, particularly in the production of antiviral and anticancer drugs.

Inhibitory Activity

The compound is an important intermediate in the production of drugs due to its ability to inhibit viral and cellular DNA and RNA synthesis.

Antifungal and Antimicrobial Properties

The compound has been studied for its potential antifungal and antimicrobial properties.

InChI:InChI=1/C12H15N5O4/c1-7-3-16(10-2-8(19)9(4-18)21-10)12(20)15-11(7)17-6-13-5-14-17/h3,5-6,8-10,18-19H,2,4H2,1H3/t8-,9+,10+/m0/s1

Upstream product

• 288-88-0 1,2,4-Triazole 
• 50-89-5 thymidine 
• 288-36-8 1,2,3-triazole 
• 10457-18-8 3',5'-bis-O-(trimethylsilyl)-thymidine 

Downstream Products

• 52417-07-9 3′,5′-di-O-trityl-thymidine 
• 50591-13-4 O⁴-methyl thymidine 
• 360048-15-3 1-(2'-deoxy-5'-O-dimethoxytrityl-β-D-ribofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2-pyrimidone 
• 25406-44-4 N,5-dimethyl-2’-deoxycytidine 
• 13957-31-8 4-thiouridine 

Relevant articles and documents

Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N-Demethylation

TET family enzymes are known for oxidation of the 5-methyl substituent on 5-methylcytosine (5mC) in DNA. 5mC oxidation generates the stable base 5-hydroxymethylcytosine (5hmC), starting an indirect, multi-step process that ends with reversion of 5mC to un

Convenient intermediates for the preparation of C-4 modified derivatives of pyrimidine nucleosides

4-(4-Nitrophenoxy)-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one 15, 5- methyl-4-(1,2,4-triazol-1-yl)-1-(β-D-2-deoxyribofuranosyl)pyrimidin-2(1H)- one 7a and 4-(4-nitrophenoxy)-1-(βD-2-deoxyribofuranosyl)pyrimidin-2(1H)- one 17a, respectively, have been prepared and are recommended as reactive intermediates for the preparation of derivatives of uridine, thymidine and 2'-deoxyuridine which are modified at C-4.