52427-40-4

Upstream product

• 13815-96-8 divinyl phenyl phosphine oxide 
• 593-51-1 methylamine hydrochloride 
• 74-89-5 methylamine 

Downstream Products

• 52427-46-0 1-methyl-4-phenyl-[1,4]azaphosphinane 4-sulfide; hydrochloride 
• 52427-45-9 1-methyl-4-phenyl-[1,4]azaphosphinane 4-sulfide 
• 52427-44-8 1-methyl-4-phenyl-[1,4]azaphosphinane 

Relevant academic research and scientific papers

Two-fragment α-adrenolytics 3. Addition of primary amines to alkyl divinylphosphinates and phenyl(divinyl)phosphine oxide

Primary alkylamines, β-aryloxyethylamines, or N-[β-(2-methoxyphenoxy)ethyl]-α,ω-diaminoalkanes react with alkyl divinylphosphinates or phenyl(divinyl)phosphine oxide to give the corresponding 4-alkoxy(4-phenyl)-1-alkyl-4-oxo-1,4-azaphosphorinanes. Reactions of the latter with mono-or dihaloalkanes afford 4-phosphapiperidinium halides. 1,4-Azaphosphorinanes containing a β-aryloxyethyl fragment exhibit hypotensive activity.

Phosphinolines and phosphindolines

This invention is for phosphinoline and phosphindoline compounds having the formula, Wherein n is 0 or 1; X is 0 or S; R3 is hydrogen or methyl; R5 is hydrogen or methyl, or may be bound to R13 to form a morpholino, piperidino or pyrrolidino ring; R7 is hydrogen or hydroxy; R11 and R12 are hydrogen; R13 is methyl, or R13 and R5 may be joined together as above stated to form a morpholino, piperidino, or pyrrolidino ring. The compounds are analgesics.