52430-93-0Relevant academic research and scientific papers
The synthesis of the novel adenosine agonists, exo- and endo-N6-(5,6-epoxynorborn-2-yl)adenosine
Scammells,Baker,Bellardinelli,Olsson,Russell,Wright
, p. 4735 - 4744 (2007/10/03)
Both racemic exo and endo isomers of N6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A1 adenosine receptor. Crucial to the preparation of these compounds is the synthesis of exo and endo norbornenylamines which are accessed through an optimised Curtius rearrangement.
Synthesis of exo-5-azidonorbornene and exo-2,exo-5-diazidinorbornene
Marchand,Sorokin,Rajagopal,Bott
, p. 3141 - 3147 (2007/10/02)
Polar addition of HN3 to norbornadiene (1) affords exo-5-azido-norbornene (2, 70%). Subsequent azidomercuration-demercuration of 2, performed by using in situ generated Hg(N3)2 followed by reductive demercuration, proceeds stereospecifically to afford exo-2,exo-5-diazidonorbornane (5, 68% yield).
