52448-14-3

Usage

Uses

Used in Biochemical Research:
(S)-2-AMINO-3-(4-CHLORO-1H-INDOL-3-YL)-PROPIONIC ACID is used as a research tool for studying biological pathways and mechanisms. Its unique structure allows scientists to probe and understand complex interactions within biological systems, which is crucial for advancing our knowledge of various diseases and their underlying causes.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, (S)-2-AMINO-3-(4-CHLORO-1H-INDOL-3-YL)-PROPIONIC ACID is utilized as a potential therapeutic target for the development of new drugs. Its role in targeting various diseases, including cancer and neurological disorders, positions it as a promising candidate for creating innovative treatments with improved efficacy and selectivity.
Used in Drug Development:
(S)-2-AMINO-3-(4-CHLORO-1H-INDOL-3-YL)-PROPIONIC ACID is employed as a building block in the synthesis of new pharmaceutical compounds. Its unique properties make it a valuable component in the design of drugs with enhanced potency and selectivity, contributing to the development of more effective treatments for a range of medical conditions.

Upstream product

• 40247-57-2 4-chloro-3-dimethylaminomethylindole 
• 1906-82-7 ethyl acetamidoacetate 
• 95-92-1 oxalic acid diethyl ester 
• 147663-90-9 acetylamino-(4-chloro-indol-3-ylmethyl)-malonic acid diethyl ester 
• 25235-85-2 4-chloro-1H-indole 
• 63352-98-7 4-chloro-3-diethylaminomethylindole 
• 24621-73-6 4-chloro-1H-indole-2-carboxylic acid 
• 56-45-1 L-serin 
• 100376-53-2 2-(2-amino-6-chlorophenyl)ethyl alcohol 
• 102493-68-5 2-(2-chloro-6-nitrophenyl)-ethanol 
• 83-42-1 6-chloro-2-nitrotoluene 

Downstream Products

• 2447-16-7 2-(4-chloro-1H-indol-3-yl)ethanamine 

Relevant academic research and scientific papers

ANTIBACTERIAL COMPOUNDS

Novel compounds having antimicrobial activitiy, in particular against Pseudomonas aeruginosa, Burkholderia cepaciaand/or Clostridium difficile, and a pharmaceutical composition containing the novel compound.

De novo Biosynthesis of “Non-Natural” Thaxtomin Phytotoxins

Thaxtomins are diketopiperazine phytotoxins produced by Streptomyces scabies and other actinobacterial plant pathogens that inhibit cellulose biosynthesis in plants. Due to their potent bioactivity and novel mode of action there has been considerable interest in developing thaxtomins as herbicides for crop protection. To address the need for more stable derivatives, we have developed a new approach for structural diversification of thaxtomins. Genes encoding the thaxtomin NRPS from S. scabies, along with genes encoding a promiscuous tryptophan synthase (TrpS) from Salmonella typhimurium, were assembled in a heterologous host Streptomyces albus. Upon feeding indole derivatives to the engineered S. albus strain, tryptophan intermediates with alternative substituents are biosynthesized and incorporated by the NRPS to deliver a series of thaxtomins with different functionalities in place of the nitro group. The approach described herein, demonstrates how genes from different pathways and different bacterial origins can be combined in a heterologous host to create a de novo biosynthetic pathway to “non-natural” product target compounds.

L-4-Chlorotryptophan from Immature Seeds of Pisum sativum and Reassignment of the Absolute Stereochemistry of N-Malonyl-4-chlorotryptophan

Free 4-chlorotryptophan (4-Cl-Trp) was isolated from immature seeds of P. sativum, identified, and its stereochemistry determined to be L-form.Reinvestigation of the N-malonyl-4-Cl-Trp isolated from the same seeds showed that the stereochemistry of the 4-Cl-Trp residue is L-form.