100376-53-2

Basic information

• Product Name: 2-(2-AMINO-6-CHLOROPHENYL)ETHAN-1-OL
• Synonyms: TIMTEC-BB SBB005689;2-(2-AMINO-6-CHLOROPHENYL)ETHAN-1-OL;2-(2-amino-6-chlorophenyl)ethanol;benzeneethanol, 2-amino-6-chloro-;Ethanol, 2-(2-amino-6-chlorophenyl)-
• CAS NO: 100376-53-2
• Molecular Formula: C₈H₁₀ClNO
• Molecular Weight: 171.62
• Mol File: 100376-53-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 82-83 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 325.6°C at 760 mmHg
• Flash Point: 150.7°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 9.27E-05mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.66±0.10(Predicted)
• CAS DataBase Reference: 2-(2-AMINO-6-CHLOROPHENYL)ETHAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-AMINO-6-CHLOROPHENYL)ETHAN-1-OL(100376-53-2)
• EPA Substance Registry System: 2-(2-AMINO-6-CHLOROPHENYL)ETHAN-1-OL(100376-53-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 100376-53-2(Hazardous Substances Data)

Usage

General Description

2-(2-amino-6-chlorophenyl)ethan-1-ol, also known as Amino-6-chlorophenylethane-1-ol, is a chemical compound with the molecular formula C8H10NOCl. 2-(2-AMINO-6-CHLOROPHENYL)ETHAN-1-OL is a phenethylamine derivative and is classified as a member of the cholorobenzene class of compounds. It is used in various industrial and research applications as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The chemical has potential applications in the fields of medicine, agriculture, and materials science due to its unique chemical properties and structure. However, it is important to handle this chemical with care as it may have harmful effects if not properly managed.

InChI:InChI=1/C8H10ClNO/c9-7-2-1-3-8(10)6(7)4-5-11/h1-3,11H,4-5,10H2

Upstream product

• 102493-68-5 2-(2-chloro-6-nitrophenyl)-ethanol 
• 7439-89-6 iron 
• 31912-08-0 (2-chloro-6-nitro-phenyl)-acetic acid 
• 89277-98-5 2-(2-chloro-6-nitrophenyl)acetonitrile 
• 56433-01-3 2-chloro-6-nitrobenzyl bromide 
• 83-42-1 6-chloro-2-nitrotoluene 
• 50-00-0 formaldehyd 
• 97522-09-3 methyl 2-(2-chloro-6-nitrophenyl)acetate 

Downstream Products

• 27542-41-2 4-chloro-D-tryptophan 
• 27542-41-2 (S)-2-amino-3-(4-chloro-1H-indol-3-yl)propanoic acid 
• 118244-93-2 4-chloro-DL-tryptophan 
• 102493-80-1 N-benzyl-4-chloro-5-(2-nitrobuten-1-yl)-2,3-dihydroindole 
• 102493-72-1 N-benzyl-4-chloro-5-(2-nitropropen-1-yl)-2,3-dihydroindole 
• 102493-81-2 1-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propylamine 
• 102493-73-2 2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine 
• 102493-71-0 N-benzyl-4-chloro-2,3-dihydroindole-5-carboxaldehyde 
• 102493-70-9 N-benzyl-4-chloro-2,3-dihydroindole 
• 20870-77-3 4-chloroindolin-2-one 
• 41910-64-9 4-chloroindoline 
• 25235-85-2 4-chloro-1H-indole 

Relevant articles and documents

L-4-Chlorotryptophan from Immature Seeds of Pisum sativum and Reassignment of the Absolute Stereochemistry of N-Malonyl-4-chlorotryptophan

Free 4-chlorotryptophan (4-Cl-Trp) was isolated from immature seeds of P. sativum, identified, and its stereochemistry determined to be L-form.Reinvestigation of the N-malonyl-4-Cl-Trp isolated from the same seeds showed that the stereochemistry of the 4-Cl-Trp residue is L-form.

Dehydrogenative and Redox-Neutral N-Heterocyclization of Aminoalcohols Catalyzed by Manganese Pincer Complexes

A new manganese catalyzed heterocyclization of aminoalcohols has been accomplished. A wide range of heterocycles were synthesized, including 1,2,3,4-tetrahydroquinolines, dihydroquinolinones, and 2,3,4,5-tetrahydro-1H-benzo[b]azepines. The reaction is performed under mild reaction conditions using air and moisture stable manganese catalysts. The desired heterocycles were obtained in good to excellent yields.

Ruthenium-Catalyzed Dehydrogenative N-Heterocyclization: Indoles from 2-Aminophenethyl Alcohols and 2-Nitrophenethyl Alcohols

Indole derivatives 3 were readily obtained from 2-aminophenethyl alcohols 1 in the presence of 2 mol percent (based on 1) of RuCl2(PPh3)3 under reflux in toluene.Indole (3a) was afforded from 2-aminophenethyl alcohol (1a) quantitatively.Other indoles (3) were also obtained in 73-99percent isolated yields from the corresponding 1, which were easily prepared by condensation between the corresponding 2-nitrotoluenes and aldehydes followed by reduction.During the reaction, a stoichiometric amount of hydrogen was spontaneously evolved into the gas phase.With a heterogeneous and homogeneous binary catalyst system, indoles were afforded in one pot from 2-nitrophenethyl alcohols 2 under a hydrogen atmosphere.