52449-12-4

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 925-90-6 ethylmagnesium bromide 
• 135-19-3 β-naphthol 
• 132377-90-3 1-<α-(1H-Benzotriazol-1-yl)benzyl>-2-naphthol 
• 294174-91-7 Benzhydryl-[2,2,2-trifluoro-eth-(E)-ylidene]-amine 
• 150350-51-9 2-(benzhydryloxy)naphthalene 
• 574-42-5 benzhydryl ether 
• 60999-93-1 2-benzhydryl-1,3-diphenylpropane-1,3-dione 
• 95-14-7 1,2,3-Benzotriazole 
• 294174-93-9 benzhydryl[2,2,2-trifluoro-1-(1H-indol-3-yl)ethyl]amine 
• 91-00-9 Benzhydrylamine 

Relevant academic research and scientific papers

Phosphomolybdic acid as a bifunctional catalyst for Friedel–Crafts type dehydrative coupling reaction

Phosphomolybdic acid (H3PMo12O40) was found to be a bifunctional catalyst for C─C bond formation via the dehydrative reaction of diarylmethanols with various nucleophiles, including 2-naphthols, indoles, benzofuran and ben

Protecting group-free use of alcohols as carbon electrophiles in atom efficient aluminium triflate-catalysed dehydrative nucleophilic displacement reactions

Benzylic and allylic alcohols are rendered electrophilic without chemical modification by the use of aluminium triflate as catalyst. The reaction succeeds with alcohol, thiol, carbon and nitrogen nucleophiles. When phenols are employed as nucleophiles, C-alkylation ensues. An advanced application of the method is demonstrated in the synthesis of 2H-chromenes and their N and S analogues.

SnBr4-promoted Friedel-Crafts type dehydrative alkylation reaction of diarylmethanols with 2-naphthol derivatives

Tin(IV) bromide was found to act as an efficient Lewis acid catalyst for the Friedel-Crafts type dehydrative alkylation reaction of diarylmethanols with 2-naphthol derivatives under mild conditions. The effects of the substituents on the substrates were systematically evaluated, and the reaction could be applied to a variety of substrates by tuning the conditions depending on the electronic properties of the starting materials.

Microwave assisted benzylation of naphthols and 4-hydroxycoumarin under catalyst & solvent free conditions

An expeditious and highly practical, microwave assisted benzylation of naphthols and 4-hydroxycoumarin has been developed under catalyst-free & solvent-free conditions. Alcohols undergo heat induced dehydration to form ethers, which collapse reversibly to form the carbocation which was captured immediately by a suitable nucleophile to furnish the benzylated compounds.

Direct alkylation of aromatics using alcohols in the presence of NaHSO 4/SiO2

Simple and efficient procedure for alkylation of aromatics from alcohols in the presence of NaHSO4/SiO2 was developed. Various triaryl methanes were obtained in good yields in short reaction time. For instance the reaction of mesitylene with benzhydrol in the presence of NaHSO4/SiO2 gave the corresponding triaryl methane in a quantitative yield. NaHSO4/SiO2 was regenerated by simple treatment and could be recycled eight times without activity loss.

An efficient and general iron-catalyzed C-C bond activation with 1,3-dicarbonyl units as a leaving groups

(Chemical Equation Presented) With our compliments: The 1,3-dicarbonyl unit has been shown to be a new and useful leaving group for iron-catalyzed bond cleavage (see scheme). This new strategy can complement the traditional Friedel-Crafts reaction and was applied in the synthesis of indene derivatives.

Organocatalyzed Friedel-Crafts arylation of benzylic alcohols

Electron-rich aromatic and heteroaromatic rings are functionalized directly with a variety of benzylic alcohols under mild conditions. The reaction is catalyzed by commercially available pentafluorophenylboronic acid, which is stable under ambient conditions and recoverable. The reaction itself is highly atom economical and produces water as the only byproduct. A Friedel-Crafts mechanism is proposed.

Benzylation and allylation of naphthols using amberlyst-15

A simple and efficient method has been developed for benzylation and allylation of naphthols by treatment of the compounds with benzylic and allylic alcohols, respectively, in the presence of amberlyst-15. Several heterogeneous catalysts were screened for

Iodine-catalyzed nucleophilic substitution reactions of benzylic alcohols

Molecular iodine efficiently catalyzes the direct nucleophilic substitution of the hydroxy group of benzylic alcohols with carbon and oxygen nucleophiles. Georg Thieme Verlag Stuttgart.

Niobium(V) pentachloride: an efficient catalyst for C-, N-, O-, and S-nucleophilic substitution reactions of benzylic alcohols

Benzylic alcohols undergo easy C-, N-, O-, and S- centered nucleophilic substitution reactions with a catalytic amount of NbCl5.