52449-76-0

Usage

General Description

Methyl 4-cyano-2-nitrobenzoate is a chemical compound used in organic synthesis and as an intermediate in the production of pharmaceuticals and other fine chemicals. It is a yellow crystalline solid with a molecular formula of C9H6N2O4 and a molecular weight of 202.15 g/mol. Methyl 4-cyano-2-nitrobenzoate is known for its strong nitro and cyano functional groups, making it a valuable building block for the synthesis of various compounds. Methyl 4-cyano-2-nitrobenzoate is used in the preparation of dyes, pigments, and agrochemicals, and it is also utilized as a reactant in the pharmaceutical industry for the synthesis of various drugs. Additionally, it is known for its potential application in chemical research and development due to its unique chemical properties and reactivity.

Upstream product

• 74-88-4 methyl iodide 
• 99277-71-1 4-bromo-2-nitrobenzoic acid 
• 158580-57-5 methyl 4-bromo-2-nitrobenzoate 
• 20132-75-6 2-nitro-4-formylamino benzoic acid methyl ester 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 

Downstream Products

• 159847-83-3 methyl 2-amino-4-cyanobenzoate 

Relevant academic research and scientific papers

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

A pharmaceutical composition comprising the compound of Formula Ia, Formula Ib, Formula Ic, or Formula Id, or a pharmaceutically acceptable salt thereof, is set forth. (Formula Ia), (Formula Ib), (Formula Ic), (Formula Id)

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds of Formula (I), including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:

Method for preparing 2-amino-4-aminomethyl methyl benzoate and hydrochloride thereof

The invention relates to the field of organic synthesis, and discloses a method for preparing 2-amino-4-aminomethyl methyl benzoate and hydrochloride thereof. The method comprises the following steps:1) sequentially contacting dimethyl terephthalate with a nitration reagent and acetic acid to obtain 3-nitro-4-methoxycarbonyl benzoic acid; (2) converting the 3-nitro-4-methoxycarbonyl benzoic acidinto 2-nitro-4-methoxycarbonyl benzoyl chloride, and enabling the 2-nitro-4-methoxycarbonyl benzoyl chloride to be in contact with ammonia gas so as to obtain methyl 2-nitro-4-formylaminobenzoate; 3)performing dehydration reaction on the 2-nitro-4-formylaminobenzoic acid methyl ester to obtain 2-nitro-4-cyanobenzoic acid methyl ester, and 4) performing reduction reaction on the 2-nitro-4-cyanobenzoic acid methyl ester to obtain 2-amino-4-aminomethyl benzoate. The preparation method has the advantages of high yield, high purity and environmental protection.

2-amino-4-methanesulfonamide preparation of methyl benzoic acid methyl ester

The invention relates to a method for preparing 2-amino-4-methanesulfonamide methylbenzoate. According to the method, dimethyl terephthalate serves as a raw material, and then 2-amino-4-methanesulfonamide methylbenzoate is prepared through nitrification, ammonolysis, dehydration, hydrogenation reduction and sulfonylation. The method has the advantages that the raw material is easy to obtain, the reaction conditions are mild, the yield is high, the byproducts are few, the pollution is little, and the like; the difficult problems in the existing mesosulfuron-methyl preparation processes that the raw material is expensive, the conditions are harsh, the pollution is serious, and the like are solved effectively.

Quinoxaline compounds

Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.