5246-88-8Relevant academic research and scientific papers
“Zero VOC” Synthetic Strategy – Aromatic Amination Reactions in Deep Eutectic Solvents
Valvi, Arun,Tiwari, Shraeddha
, p. 4933 - 4939 (2018/09/11)
Rising concern for environment hazards resulting from the use of volatile organic compounds (VOCs) is prompting many chemists to use “green” solvents like water, polyethylene glycol, ionic liquids and deep eutectic solvents (DES). With a few notable exceptions, many of these processes still need to use volatile organic solvents for the workup and isolation of products. In the present report, we demonstrate a “zero VOC” protocol which eliminates the need to use organic solvents for any stage of the reaction. As a proof of concept, nucleophilic aromatic substitution reactions of 1-halo-2,4-dinitrobenzene with secondary amines were carried out in deep eutectic solvents. The reaction workup involved the addition of water for separating the product from the DES. Evaporation of water led to recovery of the DES, which exhibited good recyclability. The reaction in deep eutectic solvents was much faster than that in many other solvents, as confirmed by the kinetic studies. An attempt was made to elucidate the origin of this rate enhancement based on analysis activation parameters and correlation with the polarity parameters. The results show that use of deep eutectic solvents can take chemists a step closer towards the “zero VOC” synthetic strategy.
PHOTOALIGNING MATERIALS
-
Page/Page column 105, (2013/04/24)
The present invention relates to polymer, homo- or copolymer or oligomer for the photoalignment of liquid crystals, especially for the planar orientation of liquid crystals, comprising a main chain and a side chain, wherein the side chain and/or main chain comprises a polar group, compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).
PHOTOALIGNING MATERIALS
-
Page/Page column 124, (2013/04/24)
The present invention relates to polymer, homo- or copolymer or oligomer, which, when irradiated with polarised light orients perpendicular to the polarization direction of polarized actinic light, for the photoalignment of liquid crystals, especially for the planar orientation of liquid crystals, and which derives from at least one monomer (I), compositions thereof, and its use for optical and electro optical devices, such as, liquid crystal devices (LCDs), especially for planar orientation of liquid crystals.
Mechanistic assessment of SNAr displacement of halides from 1-Halo-2,4-dinitrobenzenes by selected primary and secondary amines: Br?nsted and Mayr analyses
Um, Ik-Hwan,Im, Li-Ra,Kang, Ji-Sun,Bursey, Samantha S.,Dust, Julian M.
supporting information, p. 9738 - 9746 (2013/01/15)
Pseudo-first-order rate constants (kobsd) have been measured spectrophotometrically for nucleophilic substitution reactions of 1-X-2,4-dinitrobenzenes (1a-d, X = F, Cl, Br, I) with various primary and secondary amines in MeCN and H2O
A NEW SYNTHESIS OF AROMATIC AND HETEROAROMATIC NITROGEN MUSTARDS VIA 3-PYRROLINES
Palmer, Brian D,Denny, William A
, p. 601 - 610 (2007/10/02)
Reaction of aromatic and heteroaromatic halides with 3-pyrroline gives adducts which can be converted in a three-step process to nitrogen mustards.
Synthesis and Cyclization Reactions of 4--9-(3-Dimethylaminopropylamino)-1-Nitroacridines: Approaches to the Synthesis of 'Nitracrine Mustard'
Chambers, David,Denny, William A.
, p. 1055 - 1060 (2007/10/02)
Compounds which can be selectively activated to cytotoxic species in hypoxic mammalian cells have potential for the treatment of solid tumours, which uniquely contain cells in such an environment.One approach to such drugs is exemplified by the title comp
