52461-83-3

Usage

Uses

Used in Pharmaceutical Research:
1-Benzyl-3-Methylimidazolium tosylate is used as a research compound for studying the effects of benzodiazepines on the central nervous system. Its ability to bind to the benzodiazepine receptor and modulate GABA activity makes it a valuable tool in understanding the mechanisms of action of sedative, anxiolytic, and muscle relaxant drugs.
Used in Experimental Studies:
1-Benzyl-3-Methylimidazolium tosylate is used as an experimental drug in various medical conditions due to its potential therapeutic applications. Its sedative, anxiolytic, and muscle relaxant properties have been studied for their potential benefits in treating conditions such as anxiety disorders, insomnia, and muscle spasms.
Used in Drug Development:
1-Benzyl-3-Methylimidazolium tosylate is used as a lead compound in the development of new drugs with improved efficacy and safety profiles. Its unique chemical structure and pharmacological properties make it a promising candidate for the design of novel therapeutic agents targeting the benzodiazepine receptor.
Used in Laboratory Settings:
1-Benzyl-3-Methylimidazolium tosylate is used as a stable and soluble tosylate salt form in laboratory settings. Its stability and solubility properties make it suitable for use in various experimental procedures, including in vitro assays and animal studies.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 65039-11-4 3-benzyl-1-methylimidazolium bromide 
• 36443-80-8 1-benzyl-3-methylimidazolium chloride 

Relevant academic research and scientific papers

Redox Reaction: A New Route for the Synthesis of Water-Miscible Imidazolium Ionic Liquids

A novel chemical redox route was developed for the preparation of water-miscible imidazolium ionic liquids (ILs). In this method, the reaction between 1-alkyl-3-methylimidazolium bromides or 3-butyl-1-phenylimidazolium bromide and the appropriate acid reactant was promoted by the redox reaction between the bromide ion and aqueous hydrogen peroxide, with hex-1-ene as both solvent and bromine scavenger. The residual bromide ion and water contents of the prepared ILs were determined by ion chromatography and the Karl-Fischer test, respectively. This method not only produces water-miscible ILs in high purity and high yield, but also simplifies the reaction conditions in comparison with previous routes.

Hydration of alkynes using Br?nsted acidic ionic liquids in the absence of Nobel metal catalyst/H2SO4

In this study, a variety of imidazole based sulfonic acid group functionalized Br?nsted acidic ionic liquids (BAILs) were synthesized. BAILs have been successfully developed as task specific ionic liquids for hydration of alkynes under mild conditions to give high yields of ketones as a selective product. Acidity of BAILs was determined using volumetric titration and UV-visible spectroscopic methods. The Hammett acidity order and acid value of BAILs correlate well with the activity order observed for most of the BAILs in the hydration reaction of phenylacetylene. Theoretical studies demonstrate that hydrogen bonding plays a key role in tuning the acidity of BAILs. Density function theory calculations are also able to explain the difference in activity observed in these BAILs. The activity of ionic liquids was theoretically studied by computing the activation energy for the hydration reaction. Recycling experiments suggest that these novel BAILs can be reused without significant loss in activity. BAILs are simple and easy to prepare and exhibit excellent activity toward the hydration of a variety of alkynes to ketones. Moreover, the reaction involving BAILs does not involve heavy metal catalysts or H 2SO4. Novel BAILs offer several attractive features such as sustainable synthetic route, low cost, moisture stability, high yields, and recyclability.