52466-45-2Relevant academic research and scientific papers
Keto-esters
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, (2008/06/13)
Cyclohexenone esters of the general formula I STR1 or pharmaceutically acceptable acid addition salts thereof, wherein, X is oxygen or sulphur, R1 is 1. alkyl, 2. cycloalkyl, 3. alkenyl, 4. alkynyl, 5. aralkyl, 6. aryl, 7. pyridyl, 8. STR2 or 9. - (CH2)m Y in which Y is perhalogenoalkyl, hydroxy, hydroxyalkoxy, hydroxyalkoxyalkoxy, alkoxy, alkoxyalkoxy, acyloxy or alkoxycarbonyl, or Y is -S(CH2)n OZ, in which Z is acyl, m and n each represent integers of 1 to 3 R2 is 1. hydrogen, 2. alkyl, optionally substituted by alkoxy or alkoxycarbonyl, 3. alkoxycarbonyl, 4. cycloalkyl, 5. cycloalkenyl, 6. aryl, aralkyl, or aralkenyl in which the aryl portion may be substituted by alkyl, alkoxy, alkoxyalkyl, methylenedioxy, alkoxycarbonyl, perhalogenoalkyl, nitro, halogen, nitrile, aryl, dialkylaminocarbonyl, amino, alkylamino, dialkyamino or aralkoxy, 7. a saturated or unsaturated heterocyclic ring containing one or more heteroatoms and which ring may be substituted by alkyl, 8. STR3 OR 9. STR4 R3 is 1. HYDROGEN, 2. alkyl, which may be substituted with alkoxycarbonyl, carboxyl, amino, alkylamino, dialkylamino, or heterocyclic, 3. alkenyl which may be substituted with alkylcarbonyl or alkoxycarbonyl, 4. alkynyl, or 5. aralkyl, R4 is 1. alkyl, 2. alkoxyalkyl, 3. alkenyl, or 4. aralkyl, R5 is Hydrogen, alkyl, aryl or alkoxycarbonyl, and R6 is Hydrogen, alkyl or aryl; With the proviso that when R1 and R4 are ethyl, and R3, R5 and R6 are hydrogen then R2 may not be a methyl. These compounds have biological activity, particularly as anaesthetics.
