524711-33-9

Usage

Uses

Used in Pharmaceutical Synthesis:
1-[(2,5-dimethylphenyl)sulfonyl]piperazine(SALTDATA: FREE) is used as a key intermediate in the synthesis of various pharmaceuticals for its potential therapeutic applications, leveraging its diverse biological activities.
Used in Agrochemical Development:
In the agrochemical industry, 1-[(2,5-dimethylphenyl)sulfonyl]piperazine(SALTDATA: FREE) is utilized as a component in the development of products designed to protect crops from bacterial, fungal, and viral infections, capitalizing on its broad-spectrum bioactivity.
Used in Research and Development:
1-[(2,5-dimethylphenyl)sulfonyl]piperazine(SALTDATA: FREE) serves as a valuable compound in research settings, where it is used to explore new chemical reactions and investigate its potential applications in various scientific fields.
Used as a Reagent in Organic Chemistry:
1-[(2,5-dimethylphenyl)sulfonyl]piperazine(SALTDATA: FREE) is employed as a reagent in organic chemistry reactions, contributing to the synthesis of complex organic molecules and facilitating advancements in chemical research.

Upstream product

• 110-85-0 piperazine 
• 19040-62-1 2,5-dimethylbenzenesulfonyl chloride 

Relevant academic research and scientific papers

Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates bearing sulfonylpiperazine as antitumor inhibitors targeting PI3Kα

PI3K signal pathway plays a vital role in cellular functions and becomes an attractive approach for cancer therapy. Herein, a new series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivatives bearing sulfonylpiperazine based on the PI3K inhibitors and our previous research. They were screened for their PI3K inhibitory activities and anticancer effects in vitro. Biological studies indicated that compound 7m revealed the remarkable antiproliferative activity (IC50 ranging from 0.03 to 0.09 μM) against four cancer cell lines (A549, Huh7, HL60 and HCT-116). Besides, compound 7m displayed a certain selective for PI3Kα (IC50 = 0.009 μM) over PI3Kβ, γ and δ, and meanwhile, it can remarkable decreased the expression level of p-Akt (Ser473) and p-S6K. In addition, compound 7m could not only induce HCT-116 cell arrest at G1 phase in a dose-dependent manner, but also induce cell apoptosis via upregulation of Bax and cleaved-caspase 3/9, and downregulation of Bcl-2. Besides, compound 7m can remarkably inhibit the growth of tumor in vivo. The above results suggested that compound 7m could be considered as a promising PI3Kα inhibitor.