524714-13-4

Upstream product

• 524714-12-3 methyl (5S,6R,7E,9E,13E,15S)-16-(4-fluorophenoxy)-3-oxa-5,6,15-trihydroxy-7,9,13-hexadecatrien-11-ynoate 
• 524714-10-1 1,1-dimethylethyl [[(2S,3S)-3-formyl-1,4-dioxaspiro[4,5]dec-2-yl]methoxy]acetate 
• 524714-05-4 (3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butyne 
• 524714-06-5 (1E,3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butene 
• 524714-15-6 (5S,6R,7E,9E,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-3-oxahexadeca-7,9,13-trien-11-ynoic acid, t-butyl ester 
• 524714-14-5 1,1-dimethylethyl [[(2S,3R)-3-[(1E,3E,7E,9S)-10-(4-fluorophenoxy)-9-hydroxyl-1,3,7-decatrien-5-ynyl]-1,4-dioxaspiro[4,5]dec-2-yl]methoxy]ethanoate 
• 524713-91-5 1,1-dimethylethyl [[(2S,3R)-3-[(1E,3E)-6-(trimethylsilyl)-1,3-hexadien-5-ynyl]-1,4-dioxaspiro[4,5]dec-2-yl]methoxy]ethanoate 
• 524713-93-7 1,1-dimethylethyl [[(2S,3R)-3-[(1E,3E)-1,3-hexadien-5-ynyl]-1,4-dioxaspiro[4,5]dec-2-yl]methoxy]ethanoate 
• 524714-09-8 1,1-dimethylethyl [[(2S,3R)-3-(1,3-dihydroxypropyl)-1,4-dioxaspiro[4,5]dec-2-yl]methoxy]acetate 

Relevant academic research and scientific papers

Crystalline acid of lipoxin A4 analogs and method of making

This invention is directed to a crystalline acid of a lipoxin A4 analog of Formula (II): wherein: R1 is —O—, —S(O)t— (where t is 0, 1 or 2), or a straight or branched alkylene chain; andR2 is aryl (optionally su

Novel 3-Oxa Lipoxin A4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo

Lipoxin A4 (LXA4) is a structurally and functionally distinct natural product called an eicosanoid, which displays immunomodulatory and anti-inflammatory activity but is rapidly metabolized to inactive catabolites in vivo. A previous

Lipoxin A4 analogs

This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory