524717-49-5

Basic information

• Product Name: {N'-[(5-oxo-4-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetyl]-hydrazinocarbothioyl}-carbamic acid ethyl ester
• CAS NO: 524717-49-5
• Molecular Weight: 364.385
• Mol File: 524717-49-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {N'-[(5-oxo-4-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetyl]-hydrazinocarbothioyl}-carbamic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {N'-[(5-oxo-4-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetyl]-hydrazinocarbothioyl}-carbamic acid ethyl ester(524717-49-5)
• EPA Substance Registry System: {N'-[(5-oxo-4-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetyl]-hydrazinocarbothioyl}-carbamic acid ethyl ester(524717-49-5)

Safety Data

• Hazardous Substances Data: 524717-49-5(Hazardous Substances Data)

Upstream product

• 199335-40-5 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid ethyl ester 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 
• 524717-36-0 hydrazide of (4-phenyl-5-oxo-1,2,4-triazolin-1-yl)acetic acid 

Relevant articles and documents

Synthesis and some pharmacological properties of 3-(4-phenyl-5-oxo-1,2,4-triazolin-1-ylmethyl)-1,2,4-triazolin-5-thione derivatives

In the reaction of (4-phenyl- or 3,4-diphenyl-5-oxo-1,2,4-triazolin-l-ylmethyl)-carbohydrazide (IIa, IIb) with isothiocyanates the thiosemicarbazide derivatives [IIIa, b - IXa, b] were obtained. Cyclization of those compounds in the presence of 2% or 10% NaOH led to formation of derivatives with the 1,2,4-triazolin-5-thione system [Xa, b - XVIa, b]. Molecular structure proposed for this group of compounds was confirmed by X-ray structure analysis of Xa and XIVa. Compounds Xa, XIIa and XIVa were investigated pharmacologically for their central properties in mice. It was shown that only compound XIIa produced antinociceptive effects in mice.