524724-74-1

Basic information

• Product Name: 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE
• Synonyms: 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE;8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE;8-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-carbaldehyde;8-methyl-2-(4-methylphenyl)-3-imidazo[3,2-a]pyridinecarboxaldehyde;8-methyl-2-(4-methylphenyl)imidazo[3,2-a]pyridine-3-carbaldehyde;ZINC02509185
• CAS NO: 524724-74-1
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.3
• Mol File: 524724-74-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE(524724-74-1)
• EPA Substance Registry System: 8-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE(524724-74-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 524724-74-1(Hazardous Substances Data)

Upstream product

• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 619-41-0 4-(bromoacetyl)toluene 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1435395-69-9 8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime 
• 1435397-15-1 8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-cyanobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435397-08-2 8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435397-01-5 8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methoxybenzyl)1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435396-94-3 8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-[1-(4-methylbenzyl)-1H-1,2,3-triazol-4-yl]methyl oxime 
• 1435396-11-4 8-methyl-2-p-tolyl-imidazo[1,2-a]pyridine-3-carbaldehyde-O-prop-2-ynyl oxime 

Relevant articles and documents

Visible light induced tetramethylethylenediamine assisted formylation of imidazopyridines

A metal-free visible light induced C-3 formylation of imidazo[1,2-a]pyridine has been developed using tetramethylethylenediamine (TMEDA) as a one carbon source. An array of 3-formyl imidazo[1,2-a]pyridines with wide functionality are synthesized using rose bengal as a photosensitizer under ambient air.

Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors

A new series of DPP-4 inhibitors with imidazo[1,2-a]pyridine scaffold were designed by exploiting scaffold hopping strategy and docking study. Based on docking binding model, structural modifications of 2-benzene ring and pyridine moieties of compound 5a led to the identification of compound 5d with 2, 4-dichlorophenyl group at the 2-position as a potent (IC50 = 0.13 μm), selective (DPP-8/DPP-4 = 215 and DPP-9/DPP-4 = 192) and in vivo efficacious DPP-4 inhibitor. Further, molecular docking revealed that compound 5d could retain key binding features of DPP-4 with the pyridine moiety of imidazo[1,2-a]pyridine ring providing an additional π-π interaction with Phe357 of DPP-4. Compound 5d might be a promising lead for further development of novel DPP-4 inhibitor treating T2DM.

Facile synthesis of new imidazo[1,2-a]pyridines carrying 1,2,3-triazoles via click chemistry and their antiepileptic studies

The present article reports the synthesis and anticonvulsant studies of new 2-arylimidazo[1,2-a]pyridines carrying suitably substituted 1,2,3-triazoles as well as their intermediates. The structures of newly synthesized compounds were confirmed by various