52481-91-1

Basic information

• Product Name: 2,8-DIMETHYL-4-HYDROXYQUINOLINE
• Synonyms: 2,8-DIMETHYL-4(1H)-QUINOLINONE;2,8-DIMETHYL-4-QUINOLINOL;2,8-DIMETHYL-4-HYDROXYQUINOLINE;2,8-DIMETHYLQUINOLIN-4-OL;2,8-DIMETHYLQUINOLIN-4(1H)-ONE
• CAS NO: 52481-91-1
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21
• Mol File: 52481-91-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 292℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.107
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2,8-DIMETHYL-4-HYDROXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,8-DIMETHYL-4-HYDROXYQUINOLINE(52481-91-1)
• EPA Substance Registry System: 2,8-DIMETHYL-4-HYDROXYQUINOLINE(52481-91-1)

Safety Data

• Hazardous Substances Data: 52481-91-1(Hazardous Substances Data)

Usage

General Description

2,8-DIMETHYL-4-HYDROXYQUINOLINE is a chemical compound that belongs to the quinoline family. It is a derivative of quinoline and contains a hydroxyl group at the 4th carbon position, along with two methyl groups at the 2nd and 8th carbon positions. It is commonly used as an antioxidant in the rubber and plastic industry to prevent discoloration and degradation of materials due to oxidation. Additionally, this compound has been studied for its potential medicinal properties, including its anti-inflammatory and anti-microbial effects. Its unique chemical structure and properties make it useful in a variety of industrial and pharmaceutical applications.

Upstream product

• 33240-19-6 ethyl 3-[(2-methylphenyl)amino]but-2-enoate 
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• 33240-19-6 ethyl (Z)-3-(o-tolylamino)but-2-enoate 

Downstream Products

• 205997-78-0 4-ethoxy-2,8-dimethyl-quinoline 
• 135015-83-7 2,8-Dimethyl-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methoxy]quinoline hydrochloride 
• 32314-39-9 4-chloro-2,8-dimethylquinoline 
• 1392408-92-2 4,5-bis(dimethylamino)-2,8-dimethylquinoline monopicrate 

Relevant articles and documents

Microwave-assisted Synthesis of 2-methyl-4-quinolinones via combes synthesis catalyzed by acidic resin under solvent-free condition

A simple and efficient method for the synthesis of 2-methylquinolin-4(1H)- one derivatives using NKC-9-resin as reusable eco-friendly catalyst via Combes cyclization under solvent-free and microwave irradiation conditions is described. The quinolines were obtained in high yields and in short reaction times.

NaHSO4/SiO2: An efficient catalyst for the synthesis of β-enaminones and 2-methylquinolin-4(1H)-ones under solvent-free condition

An efficient and simplified protocol for NaHSO4/SiO2 catalyzed solvent-free synthesis of β-enaminone and 2-methylquinolin-4(1H)- one derivatives under microwave irradiation is described. A series of functionalized derivatives have been synthesized in shorter reaction times with moderate to good yields. The use of milder catalyst in non-conventional method offers significant advantages over conventional methods, such as higher selectivities, simplicity, solvent-free reaction and non-environmental polluting conditions.

Synthesis and antibacterial activity of new 4-alkoxy, 4-aminoalkyl and 4-alkylthioquinoline derivatives

4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7- nitroquinolines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were prepared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro- quinoline, 2,8-dimethyl-4-quinolone and 4-hyd