32314-39-9

Basic information

• Product Name: 4-CHLORO-2,8-DIMETHYLQUINOLINE
• Synonyms: 4-CHLORO-8-METHYLQUINALDINE;4-CHLORO-2,8-DIMETHYLQUINOLINE
• CAS NO: 32314-39-9
• Molecular Formula: C₁₁H₁₀ClN
• Molecular Weight: 191.66
• Mol File: 32314-39-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 182-186 C
• Boiling Point: 283.5 °C at 760 mmHg
• Flash Point: 152.4 °C
• Appearance: /
• Density: 1.188
• Vapor Pressure: 0.00538mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-2,8-DIMETHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2,8-DIMETHYLQUINOLINE(32314-39-9)
• EPA Substance Registry System: 4-CHLORO-2,8-DIMETHYLQUINOLINE(32314-39-9)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-41-22
• Safety Statements: 26-36-39
• WGK Germany: 3
• Hazardous Substances Data: 32314-39-9(Hazardous Substances Data)

Usage

General Description

4-Chloro-2,8-dimethylquinoline is a chemical compound with the molecular formula C11H10ClN. It is a heterocyclic compound featuring a quinoline ring with a chlorine atom at the 4-position and two methyl groups at the 2- and 8- positions. 4-CHLORO-2,8-DIMETHYLQUINOLINE is commonly used as a pharmaceutical intermediate and in the production of agrochemicals. It has also been studied for its potential applications in organic synthesis and material science. 4-Chloro-2,8-dimethylquinoline is a yellow-brown solid with a characteristic odor and is considered to be a hazardous chemical that requires proper handling and storage.

InChI:InChI=1/C11H10ClN/c1-7-4-3-5-9-10(12)6-8(2)13-11(7)9/h3-6H,1-2H3

Upstream product

• 15644-80-1 2,8-dimethyl-quinolin-4-ol 
• 68-12-2 N,N-dimethyl-formamide 
• 95-53-4 o-toluidine 
• 33240-19-6 ethyl 3-[(2-methylphenyl)amino]but-2-enoate 
• 52481-91-1 4-hydroxy-2,8-dimethylquinoline 

Downstream Products

• 109979-49-9 N'-(2,8-dimethyl-[4]quinolyl)-N,N-dimethyl-p-phenylenediamine 
• 51617-12-0 4-Amino-2,8-dimethylchinolin 
• 49612-06-8 4-hydrazino-2,8-dimethylquinoline 
• 87602-54-8 1-(2,8-Dimethyl-quinolin-4-yl)-4-phenyl-piperidin-4-ol 
• 79358-79-5 4-(2,8-Dimethyl-quinolin-4-ylamino)-2-hydroxy-benzoic acid ethyl ester; hydrochloride 
• 87602-50-4 (2,8-Dimethyl-quinolin-4-yl)-[4-(4-o-tolyl-piperazin-1-yl)-phenyl]-amine 
• 87602-51-5 {4-[4-(2-Chloro-phenyl)-piperazin-1-yl]-phenyl}-(2,8-dimethyl-quinolin-4-yl)-amine 
• 79340-82-2 4-(2,8-Dimethyl-quinolin-4-ylamino)-benzoic acid ethyl ester; hydrochloride 
• 79340-78-6 4-(2,8-Dimethyl-quinolin-4-ylamino)-benzoic acid methyl ester; hydrochloride 
• 79340-75-3 4-(2,8-Dimethyl-quinolin-4-ylamino)-2-hydroxy-benzoic acid methyl ester; hydrochloride 
• 87602-55-9 2,8-Dimethyl-4-(2-methyl-piperidin-1-yl)-quinoline 

Relevant articles and documents

HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS

The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.

Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier-Haack reaction

The study of the Vilsmeier-Haack reagent on 4-hydroxyquinaldines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analysis of the samples is also reported.