52492-69-0Relevant academic research and scientific papers
Interfacial properties of novel surfactants based on maleic and succinic acid for potential application in personal care
Janni, Devi Sirisha,Pandya, Niki,Rajput, Gajendra,Subramanyam, Gayathri,Varade, Dharmesh
, (2021/09/20)
Hemiesters and Hemiamides of maleic and succinic acid viz. sodium lauryl succinate (C12SE), sodium lauryl maleate (C12ME), sodium lauryl succinamide (C12SA), sodium lauryl maleamide (C12MA), sodium hexadecyl succinate (C16SE) and sodium hexadecyl maleate (C16ME) were synthesized and investigated as surfactants in the pure water and aqueous hydrotrope [sodium p-toluene sulfonate (NaPTs)] solution. The chemical structures of the prepared surfactants were established by FTIR and 1H NMR spectroscopy. The surface tension measurements depicted low CMC and a high adsorption efficiency (pC20) which is highly beneficial for creating personal care formulations. The dynamic light scattering (DLS) technique indicated the formation of larger micelles which was important for skin care as larger micelles cannot penetrate the skin layer. Moreover, these surfactants depicted good foamability and stability attributed to faster monomer adsorption and small bubble size which was preferred for cleansing application. Additionally, low protein/lipid solubilization by these surfactants indicated its mild behaviour on skin as compared to other commonly used conventional anionic [sodium lauryl sulfate (SLS)], zwitterionic [cocamidopropyl betaine (CAPB)] and nonionic [decyl glucoside (DG)] surfactants. Viscosity measurements suggested decent thickening ability of surfactants in the presence of co-surfactant like lauramine oxide. Basis of all the properties discussed, these novel hemiesters and hemiamides seem promising as surfactants for improving various characteristics in potential personal care formulations.
Continuous efficient production method for high-purity N-substituted maleamic acid
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Paragraph 0053-0054, (2018/09/08)
The invention belongs to the technical field of fine chemicals and particularly relates to a continuous efficient production method for high-purity N-substituted maleamic acid. The method comprises the following steps: solutions are prepared from primary amine and maleic anhydride respectively by inert solvents in nitrogen protective atmosphere; the two solutions are added to an efficient mixer inproportion for mixing; the mole ratio of primary amine and maleic anhydride is 1:1.0-1.5, a reaction product is treated by a solid-liquid separation unit, and the product amido carboxylic acid is separated; a liquid solution separated out by the solid-liquid separation unit and a liquid solution obtained after separation of the product amido carboxylic acid are used for preparing the primary amine and maleic anhydride solutions circularly. With adoption of the method for continuously and efficiently synthesizing high-purity N-substituted maleamic acid with high yield and high selectivity witha reaction-separation coupling control reaction technology, the adding way of primary amine and maleic anhydride and standing time of a chemical reaction are controlled, and isomerization and Michaeladdition side reactions are avoided effectively through rapid reaction and rapid separation.
Compound, application thereof, platinum coordination complex and liposome thereof
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Paragraph 0190-0194, (2017/08/31)
The invention relates to the field of medicines, in particular to a compound, application thereof, a platinum coordination complex and liposome thereof. The platinum coordination complex disclosed by the invention can be well combined with a membrane material of the liposome, so that encapsulation efficiency and drug loading capacity of the liposome are improved; furthermore, the platinum coordination complex disclosed by the invention contains carboxyl and has pH sensitivity; the carboxyl trends to be deprotonated in lower pH value environment (such as tumor tissues), so that release of medicine in the tumor tissues is improved, and a curing effect of medicine is improved. Experiments show that the liposome disclosed by the invention can reduce toxic and side effects of the medicine and improve medicine effects.
Synthesis and biological activity of a squalenoid maleimide and other classes of squalene derivatives as irreversible inhibitors of 2,3-oxidosqualene cyclase
Grosa,Viola,Ceruti,Brusa,Delprino,Dosio,Cattel
, p. 17 - 23 (2007/10/02)
New classes of squalene derivatives were rationally designed and synthesized as irreversible inhibitors of 2,3-oxidosqualene cyclase (OSC), a key enzyme in sterol biosynthesis. The derivatives synthesized were maleimide 5, disulfides 8-9, α,β-unsaturated nitriles 10-11 and oxirane 12. The inhibitor activities of these derivatives were determined in vitro on OSC associated with pig liver microsomes. Squalene and dodecyl maleimide were the best inhibitors of OSC, showing a time-dependent enzyme inactivation. Moreover 2,3-oxidosqualene (OS), the natural substrate of OSC, partially protected the enzyme from squalene maleimide inactivation whereas the dodecyl derivative did not. This fact and the complex kinetics shown by squalene maleimide suggest the presence of different classes of thiolic groups essential to the activity of OSC.
