524954-19-6Relevant articles and documents
5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase
Ballard, Peter,Bradbury, Robert H.,Hennequin, Laurent F. A.,Hickinson, D. Mark,Johnson, Paul D.,Kettle, Jason G.,Klinowska, Teresa,Morgentin, Remy,Ogilvie, Donald J.,Olivier, Annie
, p. 4226 - 4229 (2005)
Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model.
