52498-16-5

Usage

Common Uses

Chemical intermediate in polymer and plastic production
Solvent in textile manufacturing
Precursor in pharmaceutical and agrochemical synthesis

Physical State

Colorless, odorless liquid at room temperature

Flammability

Highly flammable

Toxicity

Moderately toxic

Health Hazards

Skin and eye irritation upon contact
Central nervous system depression
Respiratory distress
Gastrointestinal irritation

Exposure Risks

Inhalation or ingestion can lead to adverse health effects

Upstream product

• 2881-83-6 ethyl 4-methoxybenzoylacetate 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 15982-64-6 1,4-bis(4-methoxyphenyl)butane-1,4-dione 
• 927-77-5 n-propylmagnesium bromide 
• 64-17-5 ethanol 

Downstream Products

• 52498-17-6 1,4-Bis-(p-anisyl)-1,4-dichlor-butan 
• 52498-18-7 1,2-bis(4-methoxyphenyl)cyclobut-1-ene 
• 52498-14-3 cis-1,2-bis(4-methoxyphenyl)cyclobutane 
• 52498-15-4 trans-1,2-bis(4-methoxyphenyl)cyclobutane 

Relevant academic research and scientific papers

Transformation of zirconocene-olefin complexes into zirconocene allyl hydride and their use as dual nucleophilic reagents: Reactions with acid chloride and 1,4-diketone

Zirconocene-olefin complexes Cp2Zr(H2C=CHR), prepared in benzene-THF at 0 °C, react with acid chlorides to provide homoallylic alcohols. The key is an equilibrium between the zirconocene-olefin complexes and the corresponding zircono

Highly diastereoselective tandem reduction-allylation reactions of 1,4-diketones with zirconocene-olefin complexes

Terminal alkenes act as dual nucleophiles in a zirconocene-mediated, highly 1,4-diastereoselective, tandem reduction-allylation reaction of 1,4-diketones. A zirconocene-alkene complex (in equilibrium with an allyl-zirconocene-hydride species) can deliver both hydride and an allyl group to a diketone, with control of the relative configuration of up three new stereogenic centers (see scheme).