52498-82-5

Usage

Molecular Structure

1H-Indole, 1-(4-chlorobenzoyl)-2-methylis a chemical compound consisting of an indole ring with a 1-(4-chlorobenzoyl) group attached to the 1 position and a methyl group attached to the 2 position.

Derivation

The compound is derived from indole, a heterocyclic organic compound consisting of a benzene ring fused to a pyrrole ring.

Functional Groups

The compound contains a 4-chlorobenzoyl group and a methyl group as its functional groups.

Chemical Reactivity

1H-Indole, 1-(4-chlorobenzoyl)-2-methylmay be used in various chemical reactions and organic synthesis processes.

Potential Applications

The compound has potential applications in the pharmaceutical and agrochemical industries.

Safety Guidelines

It should be handled and used according to proper safety guidelines, as it may have potential hazards associated with its handling and use.

Upstream product

• 1002121-11-0 N-(2-allyl-phenyl)-4-chloro-benzamide 
• 589-09-3 N-allyl-N-phenylamine 
• 62-53-3 aniline 
• 32704-22-6 2-allyl-phenylamine 
• 74-11-3 para-chlorobenzoic acid 

Relevant academic research and scientific papers

Synthesis of functionalized indoles via palladium-catalyzed cyclization of N-(2-allylphenyl) benzamide: A method for synthesis of indomethacin precursor

We developed an efficient method for synthesis of substituted N-benzoylindole via Pd(II)-catalyzed C-H functionalization of substituted N-(2-allylphenyl)benzamide. The reaction showed a broad substrate scope (including N-acetyl and N-Ts substrates) and substituted indoles were obtained in good to excellent yields. The most distinctive feature of this method lies in the high selectivity for N-benzoylindole over benzoxazine, and this is the first example of Pd(II)-catalyzed synthesis of substituted N-benzoylindole. Notably, this new method was applied for the synthesis of key intermediate of indomethacin.

Indole compound and synthesizing and application methods thereof

The invention relates to an indole compound and synthesizing and application methods thereof. The indole compound is prepared by selecting specific substituent groups. Experiments find that the indolecompound can achieve good inhibiting effects on prostatic cancer, good in drug-resistance-proofness and low in side effects when applied as an anti-cancer drug; besides, the synthesizing method of the indole compound comprises subjecting a compound with the structure shown as the formula (II), palladium acetate, benzoquinones and organic acids to reaction in solvent to obtain the indole compoundwith the structure shown as the formula (I). Experiment results show that the synthesizing method of the indole compound is low in requirements on substrate and high in product yield.