52499-04-4

Usage

Uses

Used in Pharmaceutical Industry:
5-Thiazolecarboxamide, 2-amino-(9CI) is used as a potential active pharmaceutical ingredient for the development of new drugs. Its unique molecular structure may contribute to the modulation of biological targets, offering therapeutic benefits in various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Thiazolecarboxamide, 2-amino-(9CI) is utilized as a potential component in the formulation of pesticides or herbicides. Its chemical properties may enable it to interact with specific biological systems in plants or pests, providing control over unwanted organisms in agricultural settings.
Used in Organic Synthesis:
5-Thiazolecarboxamide, 2-amino-(9CI) is employed as a building block in the synthesis of other organic compounds. Its structural features make it a valuable intermediate in the creation of novel molecules with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 6633-61-0 methyl 2-aminothiazole-5-carboxylate 
• 51640-52-9 2-amino-5-cyanothiazole 

Downstream Products

• 51640-52-9 2-amino-5-cyanothiazole 
• 1033780-01-6 (E)-2-[2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxyimino-acetylamino]-thiazole-5-carboxylic acid amide 
• 1033779-97-3 (E)-2-[2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclohexyloxyimino-acetylamino]-thiazole-5-carboxylic acid amide 

Relevant academic research and scientific papers

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART). Epigenetic targeted compounds have shown promise as potential latency-reversing agents; however, these drugs have undesirable toxicity and lack specificity for HIV. We utilized a novel HEK293-derived FlpIn dual-reporter cell line, which quantifies specific HIV provirus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to identify the 5-substituted 2-acylaminothiazole hit class. Here, we describe the optimization of the hit class, defining the functionality necessary for HIV gene activation and for improving in vitro metabolism and solubility. The optimized compounds displayed enhanced HIV gene expression in HEK293 and Jurkat 10.6 latency cellular models and increased unspliced HIV RNA in resting CD4+ T cells isolated from HIV-infected individuals on ART, demonstrating the potential of the 2-acylaminothiazole class as latency-reversing agents.

Oxime glucokinase activators

Disclosed herein are pyrazole glucokinase activators of the formula (I): that are useful for the treatment of metabolic diseases and disorders.