5250-17-9

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-pyridin-2-ylprop-2-en-1-one is used as a potential pharmaceutical candidate for medicinal chemistry research and drug development. Its unique structural features and potential interactions with biological systems make it a promising compound for the development of new drugs.
Used in Natural Products Research:
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-pyridin-2-ylprop-2-en-1-one is used as a compound with potential biological activities in the study of natural products. Its structural elements commonly found in pharmaceuticals and natural products make it a valuable compound for research in this field.

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 

Relevant academic research and scientific papers

COMPOSITIONS FOR INHIBITING ANDROGEN DEPENDENT OR INDEPENDENT PROSTATE CANCER CELLS AND PHARMACEUTICAL FORMULATIONS OF PROSTATE CANCER CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide compositions for inhibiting androgen dependent or independent prostate cancer cells which are used for prostate cancer, inhibit activation of androgen receptors, are effective for inhibiting the proliferation of androgen dependent or independent prostate cancer, inhibit the action even if AR-V7 has expressed, and are effective also to anticancer drug resistant cell lines; and to provide pharmaceutical formulations of prostate cancer using the same. SOLUTION: A composition for inhibiting androgen dependent or independent prostate cancer cells comprises an α,β-saturated or unsaturated ketone derivative represented by the following chemical formula (1) or a pharmaceutically acceptable salt thereof. (X- represents a hydrocarbon aromatic ring group or an aromatic heterocyclic group, both or either of Y1- and Y2- are a hydrocarbon aromatic ring group or an aromatic heterocyclic group and the other is a hydrogen atom, Z= represents an atom or a functional group which forms or generates a ketone group, a thioketone group, an imino group, or an oxime group together with a bonding carbon atom, Y3- is a hydrogen atom, a perhalogeno hydrocarbon group or the like.) The pharmaceutical formulation of prostate cancer contains this composition. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Development of novel pesticides based on phytoalexins: Part 2. Quantitative structure-activity relationships of 2-heteroaryl-4-chromanone derivatives

Phytoalexins are low-molecular-weight chemicals that immune systems of plants produce and accumulate in response to infections, especially those of fungal origin. Although their content is not high in plants, yet they have shown unique fungicidal activity