52516-43-5

Basic information

• Product Name: (2-Chloro-3-methoxyphenyl)methanol
• Synonyms: (2-Chloro-3-methoxyphenyl)methanol;2-chloro-3-methoxybenzyl alcohol
• CAS NO: 52516-43-5
• Molecular Formula: C₈H₉ClO₂
• Molecular Weight: 172.60886
• Mol File: 52516-43-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2-Chloro-3-methoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Chloro-3-methoxyphenyl)methanol(52516-43-5)
• EPA Substance Registry System: (2-Chloro-3-methoxyphenyl)methanol(52516-43-5)

Safety Data

• Hazardous Substances Data: 52516-43-5(Hazardous Substances Data)

Usage

General Description

(2-Chloro-3-methoxyphenyl)methanol, also known as vanillyl alcohol, is an organic compound with a distinct chemical structure. It is a white crystalline solid used in the synthesis of various pharmaceuticals and fragrances. Vanillyl alcohol is also used as a flavoring agent in food and beverages due to its sweet and vanilla-like aroma. It is a derivative of vanillin, the primary compound responsible for the flavor and aroma of vanilla beans. This chemical compound has potential applications in the medical, cosmetic, and food industries, making it a valuable and versatile ingredient.

Upstream product

• 54881-49-1 2-chloro-3-methoxy benzaldehyde 
• 591-31-1 3-methoxy-benzaldehyde 
• 56962-10-8 2-chloro-3-hydroxybenzaldehyde 
• 6971-51-3 3-methoxybenzyl alcohol 
• 277331-17-6 2-chloro-3-(hydroxymethyl)phenol 
• 74-88-4 methyl iodide 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 78141-78-3 trans-α-(2-Chloro-3-methoxyphenyl)cinnamic acid 
• 78141-77-2 2-Chloro-3-methoxyphenylacetic acid 
• 52516-45-7 (2-chloro-3-methoxyphenyl)acetonitrile 
• 354138-86-6 1,3-Dichloro-2-[(E)-2-(2-chloro-3-methoxy-phenyl)-vinyl]-5-methoxy-benzene 
• 354138-97-9 1,3-Dichloro-2-[(Z)-2-(2-chloro-3-methoxy-phenyl)-vinyl]-5-methoxy-benzene 
• 817166-76-0 6-[(Z)-2-(3-Chloro-4-methoxy-2-triisopropylsilanyloxymethyl-phenyl)-vinyl]-2,2-dimethyl-[1,3]dioxin-4-one 
• 817166-54-4 3-chloro-4-methoxy-2-triisopropylsilanyloxymethyl-benzaldehyde 
• 817166-52-2 6-bromo-2-chloro-3-methoxybenzyl triisopropylsilyl ether 
• 817166-50-0 6-bromo-2-chloro-3-methoxybenzyl alcohol 
• 354138-68-4 1-(bromomethyl)-2-chloro-3-methoxybenzene 
• 33532-24-0 1-(2-Chlor-3-methoxybenzyl)-1-methylhydrazin 
• 52516-44-6 2-Chloro-3-methoxybenzyl chloride 
• 54881-49-1 2-chloro-3-methoxy benzaldehyde 

Relevant articles and documents

Methanol as hydrogen source: Transfer hydrogenation of aromatic aldehydes with a rhodacycle

A cyclometalated rhodium complex has been shown to perform highly selective and efficient reduction of aldehydes, deriving the hydrogen from methanol. With methanol as both the solvent and hydrogen donor under mild conditions and an open atmosphere, a wide range of aromatic aldehydes were reduced to the corresponding alcohols, without affecting other functional groups.

DIHYDROPYRIDINE DERIVATIVES

The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2-4C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(1-4C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(1-4C)alkyl. The compounds are useful for the treatment of fertility disorders.

Reactions of Halogenated α-Phenylcinnamic Acids with Potassium Amide in Liquid Ammonia : Part II - Mechanism of Cyclisation of ortho- and meta- Chloro-α-phenylcinnamic Acids

Reaction of trans-2-chloro-3-methoxy-α-phenylcinnamic acid (1) with KNH2/NH3 gives 4-methoxyphenanthrene-9-carboxylic acid (2).A similar treatment of 1-(2'-chlorophenyl)-2,2-diphenylethylene (15a) affords 9-phenylphenanthrene but its meta-halogenated anal