56962-10-8

Basic information

• Product Name: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
• Synonyms: 2-Chloro-3-hydroxybenzaldehyde 97%;2-CHLORO-3-HYDROXYBENZALDEHYDE 97;Benzaldehyde, 2-chloro-3-hydroxy-;2-chloro-3-hydroxy-
• CAS NO: 56962-10-8
• Molecular Formula: C₇H₅ClO₂
• Molecular Weight: 156.57
• EINECS: 1592732-453-0
• Product Categories: API intermediates;Aldehydes;C7;Carbonyl Compounds;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 56962-10-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 139-143 °C(lit.)
• Boiling Point: 245°C at 760 mmHg
• Flash Point: 102°C
• Appearance: /
• Density: 1.404g/cm³
• Vapor Pressure: 0.0188mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 7.77±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97(56962-10-8)
• EPA Substance Registry System: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97(56962-10-8)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-37/38-41-50
• Safety Statements: 26-36-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• HazardClass: 9
• PackingGroup: Ⅲ
• Hazardous Substances Data: 56962-10-8(Hazardous Substances Data)

Usage

Uses

2-chloro-3-hydroxy-Benzaldehyde is a versatile building block used in the preparation of positional isomers of NOSH-aspirin a dual nitric oxide and hydrogen sulfide releasing hybrid pharmaceutical.

InChI:InChI=1/C7H5ClO2/c8-7-5(4-9)2-1-3-6(7)10/h1-4,10H

Upstream product

• 507-40-4 tert-butylhypochlorite 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 51786-11-9 2-chloro-3-hydroxybenzonitrile 
• 917827-94-2 2-chloro-3-pyrrolidin-1-ylmethyl-phenol 
• 959909-75-2 3-(tert-butyldimethylsilyloxy)-2-chlorobenzaldehyde 
• 54881-49-1 2-chloro-3-methoxy benzaldehyde 
• 860553-73-7 4,6-dibromo-2-chloro-3-hydroxy-benzaldehyde 
• 860243-44-3 4-bromo-2-chloro-3-hydroxy-benzaldehyde 
• 51786-10-8 2-Chloro-3-hydroxy benzoic acid 
• 277331-17-6 2-chloro-3-(hydroxymethyl)phenol 
• 1019770-05-8 4-(2-chloro-3-hydroxy-phenyl)-but-3-en-2-one 
• 99586-82-0 2-chloro-3-ethoxybenzaldehyde 

Relevant articles and documents

Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications

An ortho-selective ammonium chloride salt-catalyzed direct C-H monohalogenation of phenols and 1,1′-bi-2-naphthol (BINOL) with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as the chlorinating agent has been developed. The catalyst loading was low (down to 0.01 mol %) and the reaction conditions were very mild. A wide range of substrates including BINOLs were compatible with this catalytic protocol. Chlorinated BINOLs are useful synthons for the synthesis of a wide range of unsymmetrical 3-aryl BINOLs that are not easily accessible. In addition, the same catalytic system can facilitate the ortho-selective selenylation of phenols.

BRUTON'S TYROSINE KINASE INHIBITORS

Bruton's tyrosine kinase (Btk) inhibitors have the following Formula (I).

Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues

para-Regioselective bromination of phenol and analogues, promoted by p-toluenesulfonic acid, is achieved in high to excellent yields at room temperature with N-bromosuccinimide. Chlorination with N-chlorosuccinimide and catalysed by p-toluenesulfonic acid also gives para-chlorinated phenol analogues in good yields at room temperature. para-Bromination of phenol, promoted by p-toluenesulfonic acid, is achieved in excellent yields at room temperature with N-bromosuccinimide. p-Toluenesulfonic acid is also effective as a promoter of para-chlorination with N-chlorosuccinimide.