52536-36-4

Usage

Uses

Used in Scientific Research:
1-(2-chlorophenyl)-4-(3-chloropropyl)piperazine is used as a research chemical for the study of its hallucinogenic properties and potential interactions with the human brain. It provides valuable insights into the mechanisms of action of psychedelic substances and their effects on cognitive and perceptual processes.

Upstream product

• 39512-50-0 N-(o-Chlorophenyl)piperazine 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 114694-59-6 1-[4-(2-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 114694-61-0 1-[4-(2-chloro-phenyl)-piperazino]-3-(4-p-tolyl-piperazino)-propane 
• 114694-60-9 1-[4-(2-chloro-phenyl)-piperazino]-3-(4-o-tolyl-piperazino)-propane 
• 6323-10-0 1-[4-(2-chloro-phenyl)-piperazino]-3-[4-(3-chloro-phenyl)-piperazino]-propane 
• 115098-04-9 1-[4-(2-chloro-phenyl)-piperazino]-3-[4-(4-chloro-phenyl)-piperazino]-propane 
• 91532-35-3 3-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propyl}-3H-benzo[d][1,2,3]triazin-4-one 
• 84344-60-5 1-(2-Chloro-phenyl)-4-[3-(2-nitro-phenoxy)-propyl]-piperazine 
• 174519-56-3 N¹-{3-[4-(2-Chloro-phenyl)-piperazin-1-yl]-propyl}-ethane-1,2-diamine 

Relevant academic research and scientific papers

Synthesis of new 1,2,3-benzotriazin-4-one-arylpiperazine derivatives as 5-HT(1A) serotonin receptor ligands

A series of novel 1,2,3-benzotriazin-4-one derivatives was prepared and evaluated as ligands for 5-HT receptors. Radioligand binding assays proved that the majority of the novel compounds behaved as good to excellent ligands at the 5-HT(1A) receptor, some of which were selective with respect 5-HT(2A) and 5-HT(2C) receptors. Six analogues (1a, 2a, 2b, 2c, 2e and 2i) were selected and further evaluated for their binding affinities on D1, D2 dopaminergic and α1-, α2-adrenergic receptors. A o-OCH3 derivative (2e) bound at 5-HT(1A) sites with subnanomolar affinity (IC50=0.059 nM) and shows high selectivity over all considered receptors and may offer a new lead for the development of therapeutically efficacious agents. Copyright (C) 2000 Elsevier Science Ltd.

Synthesis and trazodone-like pharmacological profile of 1- and 2--propyl>benzotriazoles

A series of 1- and 2--propyl>benzotriazoles were prepared and evaluated for their trazodone-like pharmacological profile; as preliminary pharmacological screening, the compounds were tested for their antiserotonergic, antiadrenergic and antihistaminic in vitro activity as well as for their analgesic in vivo action.Structure-activity relationships showed that among the synthesized compounds, the analogues bearing on the 4-piperazine nitrogen either an unsubstituted phenyl ring or a 2- or 3-chloro phenyl moiety show a pharmacological profilesimilar to that of the antidepressant trazodone. benzotriazoles / antiserotonergic / antiadrenergic / antihistaminic/ analgesic

Synthesis and Biological Activities of 3-Substituted 1-Aryloxyaminopropanes

A number of 3-substituted 1-aryloxyaminopropanes (9-43) have been prepared by the reaction of appropriate hydroxyaryl compound with 1-chloro-3-1-(N4-aryl-piperazinyl/piperidinyl)>propanes (1-8).The 1-(6/7-quinolyloxy)-3-substituted