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52573-74-7

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52573-74-7 Usage

Description

N1-ISOPROPYL-2-CYANOACETAMIDE, a chemical compound with the molecular formula C6H10N2O, is a cyanamide derivative and a member of the acetamide family. It is characterized by the presence of an isopropyl group and a cyano group, which contribute to its versatility in organic synthesis. N1-ISOPROPYL-2-CYANOACETAMIDE is widely recognized for its pharmaceutical and industrial applications, primarily as a chemical intermediate in the synthesis of various drugs, agrochemicals, and other fine chemicals.

Uses

Used in Pharmaceutical Industry:
N1-ISOPROPYL-2-CYANOACETAMIDE is used as a building block for the creation of various drugs due to its versatile chemical structure. It serves as a key intermediate in the synthesis of pharmaceuticals, enabling the development of new and innovative medications.
Used in Agrochemical Production:
N1-ISOPROPYL-2-CYANOACETAMIDE is utilized in the production of agrochemicals, where it acts as a valuable intermediate in the synthesis of various agricultural chemicals. Its presence in these products helps to enhance their effectiveness and performance in crop protection and other agricultural applications.
Used in Fine Chemicals Industry:
N1-ISOPROPYL-2-CYANOACETAMIDE is also employed in the synthesis of fine chemicals, where its unique structure and properties contribute to the development of high-quality specialty chemicals for various applications, including research, manufacturing, and other industrial processes.

Check Digit Verification of cas no

The CAS Registry Mumber 52573-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,5,7 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 52573-74:
(7*5)+(6*2)+(5*5)+(4*7)+(3*3)+(2*7)+(1*4)=127
127 % 10 = 7
So 52573-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N2O/c1-5(2)8-6(9)3-4-7/h5H,3H2,1-2H3,(H,8,9)

52573-74-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-cyano-N-propan-2-ylacetamide

1.2 Other means of identification

Product number -
Other names 2-cyano-N-isopropylacetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52573-74-7 SDS

52573-74-7Relevant articles and documents

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors

Tang, Jing,Huber, Andrew D.,Pineda, Dallas L.,Boschert, Kelsey N.,Wolf, Jennifer J.,Kankanala, Jayakanth,Xie, Jiashu,Sarafianos, Stefan G.,Wang, Zhengqiang

supporting information, p. 179 - 192 (2019/01/04)

Chronic hepatitis B virus (HBV) infection represents a major health threat. Current FDA-approved drugs do not cure HBV. Targeting HBV core protein (Cp) provides an attractive approach toward HBV inhibition and possibly infection cure. We have previously identified and characterized a 5-amino-3-methylthiophene-2,4-dicarboxamide (ATDC) compound as a structurally novel hit for capsid assembly effectors (CAEs). We report herein hit validation through studies on absorption, distribution, metabolism and excretion (ADME) properties and pharmacokinetics (PK), and hit optimization via analogue synthesis aiming to probe the structure-activity relationship (SAR) and structure-property relationship (SPR). In the end, these medicinal chemistry efforts led to the identification of multiple analogues strongly binding to Cp, potently inhibiting HBV replication in nanomolar range without cytotoxicity, and exhibiting good oral bioavailability (F). Two of our analogues, 19o (EC50 = 0.11 μM, CC50 > 100 μM, F = 25%) and 19k (EC50 = 0.31 μM, CC50 > 100 μM, F = 46%), displayed overall lead profiles superior to reported CAEs 7–10 used in our studies.

Development and SAR of functionally selective allosteric modulators of GABAA receptors

Alhambra, Cristobal,Becker, Chris,Blake, Timothy,Chang, Amy,Damewood Jr., James R.,Daniels, Thalia,Dembofsky, Bruce T.,Gurley, David A.,Hall, James E.,Herzog, Keith J.,Horchler, Carey L.,Ohnmacht, Cyrus J.,Schmiesing, Richard Jon,Dudley, Adam,Ribadeneira, Maria D.,Knappenberger, Katherine S.,MacIag, Carla,Stein, Mark M.,Chopra, Maninder,Liu, Xiaodong F.,Christian, Edward P.,Arriza, Jeffrey L.,Chapdelaine, Marc J.

experimental part, p. 2927 - 2938 (2011/06/21)

Positive modulators at the benzodiazepine site of α2- and α3-containing GABAA receptors are believed to be anxiolytic. Through oocyte voltage clamp studies, we have discovered two series of compounds that are positive modulators at α2-/α3-containing GABAA receptors and that show no functional activity at α1-containing GABA A receptors. We report studies to improve this functional selectivity and ultimately deliver clinical candidates. The functional SAR of cinnolines and quinolines that are positive allosteric modulators of the α2- and α3-containing GABAA receptors, while simultaneously neutral antagonists at α1-containing GABAA receptors, is described. Such functionally selective modulators of GABAA receptors are expected to be useful in the treatment of anxiety and other psychiatric illnesses.

A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus1

Arhin, Francis,Belanger, Odette,Ciblat, Stephane,Dehbi, Mohammed,Delorme, Daniel,Dietrich, Evelyne,Dixit, Dilip,Lafontaine, Yanick,Lehoux, Dario,Liu, Jing,McKay, Geoffrey A.,Moeck, Greg,Reddy, Ranga,Rose, Yannick,Srikumar, Ramakrishnan,Tanaka, Kelly S.E.,Williams, Daniel M.,Gros, Philippe,Pelletier, Jerry,Parr Jr., Thomas R.,Far, Adel Rafai

, p. 5812 - 5832 (2007/10/03)

The RNA polymerase holoenzyme is a proven target for antibacterial agents. A high-throughput screening program based on this enzyme from Staphylococcus aureus had previously identified a 2-ureidothiophene-3-carboxylate as a low micromolar inhibitor. An investigation of the relationships between the structures of this class of compounds and their inhibitory- and antibacterial activities is described here, leading to a set of potent RNA polymerase inhibitors with antibacterial activity. Characterization of this bioactivity, including studies of the mechanism of action, is provided, highlighting the power of the reverse chemical genetics approach in providing tools to inhibit the bacterial RNA polymerase.

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