52596-85-7

Upstream product

• 201230-82-2 carbon monoxide 
• 5033-28-3 4-chloro-N'-hydroxybenzimidamide 
• 99-94-5 p-Toluic acid 
• 132033-35-3 4-Methylbenz(N-acetyl))imidsaeure-ethylester 
• 5033-28-3 4-chlorobenzamidoxime 
• 104-81-4 4-Methylbenzyl bromide 
• 6277-45-8 1-(2-oxo-2-(p-tolyl)ethyl)pyridin-1-ium iodide 

Downstream Products

• 72093-97-1 3'-(4-chloro-phenyl)-5-phenyl-3,5'-(4,4'-trans-ethene-1,2-diyl-diphenyl)-bis-[1,2,4]oxadiazole 
• 53349-70-5 3-(4-chloro-phenyl)-5-{4-[trans-2-(2-phenyl-benzofuran-6-yl)-vinyl]-phenyl}-[1,2,4]oxadiazole 
• 53349-64-7 3-(4-chloro-phenyl)-5-[4-(4-trans-styryl-trans-styryl)-phenyl]-[1,2,4]oxadiazole 
• 53349-67-0 5-[4-(4-benzofuran-2-yl-trans-styryl)-phenyl]-3-(4-chloro-phenyl)-[1,2,4]oxadiazole 
• 52596-54-0 2-(4-{4-[3-(4-chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-2H-benzo[1,2,3]triazole 
• 65204-77-5 3-(4-chloro-phenyl)-5-{4-[4-(5-chloro-2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 65204-92-4 3-(4-chloro-phenyl)-5-{4-[4-(4-chloro-5-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 65204-83-3 3-(4-chloro-phenyl)-5-{4-[4-(2,5-diphenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 65238-72-4 3-(4-chloro-phenyl)-5-{4-[4-(4,5-diphenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 61520-02-3 3-(4-chloro-phenyl)-5-{4-[2-(2-phenyl-2H-[1,2,3]triazol-4-yl)-vinyl]-phenyl}-[1,2,4]oxadiazole 
• 65965-66-4 2-(4-{4-[3-(4-chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-styryl}-phenyl)-[1,2,4]triazolo[1,5-a]pyridine 
• 59151-87-0 3-(4-chloro-phenyl)-5-{4-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 59151-84-7 3-(4-chloro-phenyl)-5-{4-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-[1,2,4]oxadiazole 
• 52659-03-7 2-(4-{4-[3-(4-chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-trans-styryl}-phenyl)-2H-naphtho[1,2-d][1,2,3]triazole 

Relevant academic research and scientific papers

Direct synthesis of 3,5-diaryl-1,2,4-oxadiazoles using 1-(2-oxo-2-arylethyl)pyridin-1-iums with benzamidines

An efficient domino protocol for the synthesis of 1,2,4-oxadiazole derivatives from readily available 1-(2-oxo-2-arylethyl)pyridin-1-iums and amidine hydrochlorides was developed. In this practical approach, N-acyl amidine precursors were formed firstly via a simple nucleophilic substitution, without the purification of N-acylamidine intermediates, and the following intramolecularly dehydrative cyclization gave 1,2,4-oxadiazole derivatives in the presence of I2/K2CO3/DMSO, which exhibited excellent functional group tolerance and proceeded under simple experimental conditions.

An efficient method for the one-pot tandem synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from benzyl halides

The first example of a one-pot tandem approach for the synthesis of 3,5-disubstituted-1,2,4-oxadiazole derivatives from benzyl halides and amidoxime is reported. Derivatives of 3,5-disubstituted 1,2,4-oxadiazole were obtained in excellent yields under mil

Novel synthesis of 1,2,4-oxadiazoles by condensation of arylamidoximes with N-substituted iminoethers

A new efficient route to 3,5-disubstituted-1,2,4-oxadiazoles 4a-j has been performed via the one-step reaction between arylamidoximes 1a-e and N-substituted iminoethers 2a-c. The structures of compounds 4 have been elucidated by mass spectrometry, infrared and 1H, 13C NMR measurements.

The accelerated development of an optimized synthesis of 1,2,4-oxadiazoles: Application of microwave irradiation and statistical design of experiments

Herein, we report the development of an optimized microwave-assisted synthesis of 1,2,4-oxadiazoles. The chemistry development process was significantly accelerated by employing a statistical software package (MODDE 6.0) to guide in the optimization of the reaction conditions. The resulting optimized reaction conditions were then utilized in the synthesis of a focused library of 1,2,4-oxadiazoles.

Hypervalent iodine in synthesis. 75. A convenient synthesis of oxadiazoles by palladium-catalyzed carbonylation and cyclization of diaryliodonium salts and amidoximes

3,5-Disubstituted-1,2,4-oxadiazoles were prepared in one-pot procedure in moderate yields via the palladium-catalyzed carbonylation of diaryliodonium salts with amidoximes under one atmosphere of carbon monoxide followed by intramolecular dehydrative cycl