52598-53-5Relevant academic research and scientific papers
Pd/PTABS: Low Temperature Etherification of Chloroheteroarenes
Bhilare, Shatrughn,Murthy Bandaru, Siva Sankar,Shah, Jagrut,Chrysochos, Nicolas,Schulzke, Carola,Sanghvi, Yogesh S.,Kapdi, Anant R.
, p. 13088 - 13102 (2018/10/25)
A mild, general, and highly efficient catalytic etherification protocol for chloroheteroarenes was developed using the Pd/PTABS catalytic system. The protocol is selective for the etherification of chloroheteroarenes using a large variety of electron-rich and electron-deficient phenol bearing synthons which include inter alia biologically and commercially important estrone, estradiol, tyrosine, and several other molecules. The mildness of the new protocol is expected to be beneficial for the synthesis of complex drugs and drug intermediates offering late-stage modification of bioactive compounds.
Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis
Takise, Ryosuke,Isshiki, Ryota,Muto, Kei,Itami, Kenichiro,Yamaguchi, Junichiro
supporting information, p. 3340 - 3343 (2017/03/15)
Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.
Synthese de la benzopyrannoquinoxalinone-12
Vinot, Nicole,Maitte, Pierre
, p. 349 - 352 (2007/10/02)
3-Benzyl-2-quinoxalinones were obtained by condensation of o-phenylenediamine with phenylpyruvic acids.These quinoxalinones were easily substituted in position 2 and which permitted the preparation of many derivatives, however, cyclisation of these compou
