526-31-8

Usage

Uses

Used in Pharmaceutical Industry:
L-ABRINE is used as an active pharmaceutical ingredient for its potential therapeutic effects. The expression is: L-ABRINE is used as an active pharmaceutical ingredient for its potential therapeutic effects.
Used in Research and Development:
L-ABRINE is used as a research compound for studying its chemical properties and exploring its potential applications in various fields. The expression is: L-ABRINE is used as a research compound for studying its chemical properties and exploring its potential applications in various fields.
Used in Chemical Synthesis:
L-ABRINE can be used as a starting material or intermediate in the synthesis of various complex organic compounds. The expression is: L-ABRINE is used as a starting material or intermediate in the synthesis of various complex organic compounds.
Used in Analytical Chemistry:
L-ABRINE can be employed as a reference compound or standard in analytical chemistry for the identification and quantification of related compounds. The expression is: L-ABRINE is used as a reference compound or standard in analytical chemistry for the identification and quantification of related compounds.

Biochem/physiol Actions

An indoleamino acid that shows radical scavenging and antioxidant properties in vitro.

Purification Methods

Crystallise L-abrine from H2O or EtOH/H2O mixture and dry it for 2days at 60o in high vacuum; it has m 275-290o(dec with browning at 230o) and [] D +47.2o (c 2, 0.5N HCl) [Peter et al. Helv Chim Acta 46 577 1963]. [Gregory & Morley J Chem Soc 913 1968, Beilstein 22/14 V 40.]

InChI:InChI=1/C12H14N2O2/c1-13-11(12(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,13-14H,6H2,1H3,(H,15,16)/t11-/m0/s1

Upstream product

• 485-80-3 S-adenosyl-L-methionine 
• 73-22-3 L-Tryptophan 

Downstream Products

• 141408-33-5 N^α-(tert-butoxycarbonyl)-N^α-methyl-L-tryptophan 
• 141408-80-2 Boc-(N-Me)Trp-Lys(CBz)-Asp(OBn)-Phe-NH₂ 
• 153507-82-5 Boc-(N-Me)Trp-Lys(CONH-Ph-o-Me)-(N-Me)Asp-Phe-NH₂ 
• 141408-81-3 Boc-(N-Me)Trp-Lys(CONH-Ph-o-Me)-Asp-Phe-NH₂ 
• 153507-91-6 Boc-(N-Me)Trp-Lys-Asp-Phe-NH₂ 
• 171007-24-2 3-(3'-indolyl)-(2S)-(N-methyl-N-phenylacetamino)-1,1-di(4''-methylphenyl)-1-propanol 
• 171007-15-1 (2S)-(N-benzoyl-N-methylamino)-3-(3'-indolyl)-1,1-di(4''-methylphenyl)-1-propanol 
• 171007-26-4 3-(3'-indolyl)-(2S)-(N-methyl-N-3'',3''-dimethylbutyrylamino)-1,1-di(4'''-methylphenyl)-1-propanol 
• 171007-25-3 3-(3'-indolyl)-(2S)-(N-isovaleryl-N-methylamino)-1,1-di(4''-methylphenyl)-1-propanol 
• 171007-19-5 3-(3'-indolyl)-(2S)-(N-methylamino)-1,1-di(2''-methylphenyl)-1-propanol 
• 171007-18-4 3-(3'-indolyl)-(2S)-(N-methylamino)-1,1-di(4''-methylphenyl)-1-propanol 

Relevant academic research and scientific papers

Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata

Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC50 values of 0.13 nM and 1.1 μM.

Iterative l-Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication

Psilocybe mushrooms are best known for their l-tryptophan-derived psychotropic alkaloid psilocybin. Dimethylation of norbaeocystin, the precursor of psilocybin, by the enzyme PsiM is a critical step during the biosynthesis of psilocybin. However, the “magic” mushroom Psilocybe serbica also mono- and dimethylates l-tryptophan, which is incompatible with the specificity of PsiM. Here, a second methyltransferase, TrpM, was identified and functionally characterized. Mono- and dimethylation activity on l-tryptophan was reconstituted in vitro, whereas tryptamine was rejected as a substrate. Therefore, we describe a second l-tryptophan-dependent pathway in Psilocybe that is not part of the biosynthesis of psilocybin. TrpM is unrelated to PsiM but originates from a retained ancient duplication event of a portion of the egtDB gene that encodes an ergothioneine biosynthesis enzyme. During mushroom evolution, this duplicated gene was widely lost but re-evolved sporadically and independently in various genera. We propose a new secondary metabolism evolvability mechanism, in which weakly selected genes are retained through preservation in a widely distributed, conserved pathway.

Compounds and compositions for treating infection

Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.