52601-73-7Relevant academic research and scientific papers
Synthesis of a series of triaza-macrocyclicanes
Gao, Jinzhang,He, Hui,Zhang, Xuan,Lu, Xiaoquan,Kang, Jingwan
, p. 372 - 375 (2007/10/03)
Condensation of the N, N′, N″-tris(p-toluenesulfonyl)diethylenetrimine-N,N″-disodium with bissulphonate esters of two-, three-, four- and six-carbon diols gives the corresponding 9-, 10-,11-, 13-membered triamine macrocycles containing N-ptoluenesulfonyl group, respectively. The p-tuluenesulfonyl groups are removed with concentrated sulfuric acid, acetic acidhydrobromic acid or LiAlH4 which give the ammonium salts of 1,4,7-triazacyclononane, 1,4,7-triazacyclodecane, 1,4,7-triazacycloundecane, 1,4,7-triazacyclotridecane, respectively. Comparison and details of the different synthetic procedures of the triamine macrocycles are described as well.
