52601-80-6

Usage

Uses

N,N′,N′′-Tritosyldiethylenetriamine disodium salt may be used in the preparation of tritosylate of 1,4,7-triazacyclononane, via reaction with 1,2-dibromoethane in DMF. It may be used in the preparation of 1,4,7-triazacyclononane, via reaction with ditosyl derivative of 1,2-ethanediol.

General Description

N,N′,N′′-Tritosyldiethylenetriamine is a tosyl derivative and its complexation with Ag(I) and Cu(II) is reported.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 56187-04-3 1,4,7-tritosyl-1,4,7-triazaheptane 

Downstream Products

• 60147-30-0 10,13,16-tris(p-tolylsulphonyl)-1,4,7-trioxa-10,13,16-triazacyclo-octadecane 
• 72791-77-6 3-({2-[(2-{2-[benzyl-(toluene-4-sulfonyl)-amino]-ethyl}-(toluene-4-sulfonyl)-amino)-ethyl]-(toluene-4-sulfonyl)-amino}-ethyl)-oxazolidin-2-one 
• 60147-38-8 5,8,11-tris-(toluene-4-sulfonyl)-1-oxa-5,8,11-triaza-cyclotetradecane 
• 60147-29-7 7,10,13-tris(p-tolylsulphonyl)-1,4-dioxa-7,10,13-triazacyclopentadecane 
• 78668-28-7 3,6,9-tris-(toluene-4-sulfonyl)-3,6,9,15-tetraaza-bicyclo[9.3.1]pentadeca-1⁽¹⁴⁾,11⁽¹⁵⁾,12-triene 
• 52667-88-6 cyclen tetratosylate 
• 132066-11-6 1-Phenyl-4,7,10-tris-(toluene-4-sulfonyl)-1,4,7,10-tetraaza-cyclododecane 
• 128184-05-4 13-bromo-3,6,9-tritosyl-3,6,9,15-tetraazabicyclo<9.3.1>pentadeca-1(15),11,13-triene 
• 76102-76-6 6,9,12-tris(p-tolylsulfonyl)-6,9,12-triaza-1,17-bis<(tetrahydropyran-2-yl)oxy>heptadecane 
• 77416-54-7 4,7,10-tris(p-tolylsulfonyl)-4,7,10-triaza-1,13-bis<(tetrahydropyran-2-yl)oxy>tridecane 
• 56187-01-0 1,4,7,13,16,19-hexakis(p-tolylsulfonyl)-1,4,7,13,16,19-hexaazacyclotetracosane 
• 77416-55-8 5,8,11-tris(p-tolylsulfonyl)-5,8,11-triaza-1,15-bis<(tetrahydropyran-2-yl)oxy>pentadecane 
• 125683-04-7 3,6,9,17,25-pentatosyl-3,6,9,17,25,31,32,33-octaazatetracyclo<25.3.1.1^11,15.1^19,23>tritriaconta-1(31),11(32),12,14,19(33),20,22,27,29-nonaene 
• 125683-01-4 3,6,9,17,21,25-hexatosyl-3,6,9,17,21,25,31,32-octaazatricyclo<25.3.1.1^1,15>dotriaconta-1(31),11(32),12,14,27,29-hexaene 

Relevant academic research and scientific papers

METHOD FOR PREPARING NOTA DERIVATIVE

The present invention discloses Method for preparing NOTA derivative. Firstly, take 4-methylsulfonyl chloride and diethylenetriamine in tosyl group reaction to obtain the first product. And, take the first product and sodium methoxide in the first substitution reaction to obtain the second product. Further, take 4-methylsulfonyl chloride and ethylene glycol in tosyl group reaction to obtain a third product. The second product is coupled to the third product to obtain a fourth product. Take the fourth product and sulfuric acid in the second substitution reaction. Finally, a final product is obtained by a bonding reaction with hydrochloric acid. The preparation method improves the water absorption issue of the benzene ring structure compound (TACN) of the NOTA derivative.

METHOD FOR PREPARING NOTA DERIVATIVE

A method for preparing a NOTA derivative is revealed. The method includes a plurality of steps. First take 4-toluenesulfonyl chloride and diethylenetriamine to carry out tosylation reaction and obtain a first product. Then the first substitution reaction takes place upon addition of the first product with sodium methoxide to get the second product. Next take 4-toluenesulfonyl chloride to react with ethylene glycol for preparing a third product by tosylation reaction therebewteen. Then a coupling reaction between the third product and the second product is carried out to produce a fourth product. The second substitution reaction occurs involving the fourth product in the presence of sulfuric acid. Lastly take the reaction product and hydrochloric acid to have bonding reaction and obtain a final product. The method solves the water-absorption problem of the cyclic organic compound TACN, a NOTA derivative.

Contrast Agents for Magnetic Resonance Imaging

The invention relates to contrast agents for magnetic resonance imaging comprising a chelating ligand and a transition metal ion, said ligand carrying a substituent capable of reacting chemically or biochemically with a target substance while bringing about a change in the spin state.

Synthesis of N-quaternary ammonium [3H] and [(99m)Tc]Polyazamacrocycles, potential radiotracers for cartilage imaging

The [3H] and [(99m)Tc] synthesis of three new compounds, N-[3-(pyridinio)propyl] cyclam (NPPC), N-[3-(triethylammonium)propyl] cyclam (NTPC) and N-[3-(triethylammonium)propyl]-15ane-N5 (NTP 15-5), potential tracers for cartilage, is reported. NPPC and NTPC were labelled with tritium on the ethyl group of cyclam with a specific radioactivity of 89 MBq/mmol. The [(99m)Tc]-labelling of the three quaternary ammonium chelates was realized with a high specific activity in the range 20-25 MBq/μmol.

Improved synthesis and application of lanthanide 1,4,7,10-tetrakis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane complexes Ln(DOTP)

Complexes of lanthanides with 1,4,7,10-tetrakis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane (DOTP) were synthesized for use as shift reagents in a study on the three-dimensional structure of the gene-5 protein encoded by Coli-phage M13.The

Synthesis of Polyaza Macrocyclic Ligands Incorporating Pyridine Units

The synthesis of nine macrocyclic polyamines 2-10 containing pyridine units is described.These compounds are 22-(9), 24-(2-4,6,8,10), or 26-(5,7) membered hexaaza (2,3,9,10) or octaaza (4-7) macrocycles in which one to four pyridine units are incorporated