52604-94-1Relevant academic research and scientific papers
Method of treating abnormal concentrations of TNF α
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, (2008/06/13)
Compounds of the structure STR1 wherein R is selected from the group consisting of hydrogen, alkyl radicals of 1-6 carbon atoms, the phenyl radical, and the benzyl radical; and wherein R' is selected from the group consisting of the phthalimido radical and the succinimido radical and of the structure STR2 wherein X is CH2 or C=O; R" is H, --CH2 CH3, --C6 H5, --CH2 C6 H5, --CH2 CH=CH2, or STR3 and hydrolysis products of said compounds wherein R" is H and the piperidino ring or both the piperidino and the imido ring are hydrolyzed are useful for the control of abnormal concentrations of TNF α manifested in septic shock, cachexia and HIV infection without substantially effecting the concentration of other cytokines.
