603-54-3

Basic information

• Product Name: 1,1-diphenylurea
• Synonyms: Asym-Diphenylurea
• CAS NO: 603-54-3
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 212.2472
• EINECS: 210-048-6
• Mol File: 603-54-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 189°C
• Boiling Point: 352.09°C (rough estimate)
• Flash Point: 170.7°C
• Appearance: /
• Density: 1.2760
• Refractive Index: 1.6920 (estimate)
• PKA: 15.11±0.50(Predicted)
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 1,1-diphenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-diphenylurea(603-54-3)
• EPA Substance Registry System: 1,1-diphenylurea(603-54-3)

Safety Data

• Hazardous Substances Data: 603-54-3(Hazardous Substances Data)

Usage

Chemical Properties

white crystals

Air & Water Reactions

1,1-diphenylurea may be sensitive to prolonged exposure to air or light. . Insoluble in water.

Reactivity Profile

1,1-diphenylurea is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Fire Hazard

Flash point data for 1,1-diphenylurea are not available, but 1,1-diphenylurea is probably combustible.

Purification Methods

Crystallise 1,1-diphenylurea from MeOH. [Beilstein for 1,3 12 IV 741.]

InChI:InChI=1S/C13H12N2O/c14-13(16)15(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,14,16)

Upstream product

• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 62-53-3 aniline 
• 22625-57-6 5-(chloromethyl)-1,3-oxazolidin-2-one 
• 827-42-9 5-phenyl-3H-1,2-dithiol-3-one 
• 1199-02-6 5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 563-79-1 2,3-Dimethyl-2-butene 
• 1115-12-4 carbonyl cyanide 
• 83-25-0 N-phenylmaleimide 
• 64-17-5 ethanol 
• 6320-72-5 4-nitrophenyl-N-phenyl carbamate 
• 110-21-4 hydrazodicarboxamide 
• 142-04-1 aniline hydrochloride 
• 959-32-0 N-(benzoyloxy)benzamide 
• 18956-87-1 10H-phenothiazine-10-carbonyl chloride 

Downstream Products

• 4930-03-4 phenyl N-phenylcarbamate 
• 4456-80-8 N,N'-diphenyladipamide 
• 509-77-3 3,3-bis(4-aminophenyl)isobenzofuran-1-(3H)-one 
• 10312-53-5 3,3-bis-(4-amino-phenyl)-2,3-dihydro-isoindol-1-one 
• 6488-59-1 diphenylparabanic acid 
• 7391-60-8 1,3-diphenylbarbituric acid 
• 587-90-6 bis-N,N'-(4-nitrophenyl)urea 
• 2908-76-1 bis(2,4-dinitrophenyl)amine 
• 6341-55-5 N,N'-bis(p-bromophenyl)urea 
• 20632-35-3 bis(2,4,6-trichlorodiphenyl)urea 
• 2788-21-8 N,N'-dichloro-N,N'-diphenyl-urea 
• 100398-93-4 diphenyl-trichlorophosphoranyliden-urea 
• 500693-57-2 N,N'-bis-(2,4-dinitro-phenyl)-urea 
• 82200-77-9 N-(4-chloro-phenyl)-N'-(2,4-dichloro-phenyl)-urea 

Relevant articles and documents

One-pot radiosynthesis of [13N]urea and [13N] carbamate using no-carrier-added [13N]NH3

The aim of this study was to develop a practical labeling method of [ 13N]ligands using no-carrier-added [13N]NH3 with high specific activity. [13N]urea analogues [13N]1a and [13N]2a or [13N]carbamate [13N]3a were synthesized by reacting isocyanate 5a, carbamoyl chloride 6a or chloroformate 7a with [13N]NH3. The precursors 5a-7a were prepared by treating amines 8a and 9a and alcohol 10a with triphosgene in situ. These reaction mixtures were not purified and were used directly for [ 13N]ammonolysis, respectively. Using the one-pot method, we synthesized [13N]carbamazepine ([13N]4), a putative positron emission tomography ligand for brain imaging. Copyright

Novel alpha-cyano-beta-oxopropionamides

α-(Substituted carbamoyl)-β-aryl- and heteroaryl-β-oxo-propionitriles of formula, , A-CO- enol ethers thereof and salts thereof, as well as pharmaceutical preparations containing same and methods of preparing and using these compounds are disclosed. Said compounds represent novel antiinflammatory and antirheumatic agents. Their property to interfere with both the cyclooxygenase and lipoxygenase pathway of the arachidonic fatty acid bioconversion to inflammatory mediators make them valuable therapeutics. These properties render the mentioned substituted carbamoyl-β-oxopropionitriles useful for the treatment of arthritic and rheumatic diseases and other inflammatory conditions in mammals.

Method of manufacturing aromatic urethane

This invention is a method of manufacturing aro-matic urethane including an aromatic urea production step of reacting an aromatic primary amine, an aromatic nitro-compound, and carbon monoxide with one another, using a catalyst mainly consisting of a compound con-taining a platinum group metal, and using a compound having a coordination ability to the catalyst as at least part of a solvent, thereby producing N,N?-di--substituted urea, and separating and isolating the produced N,N?-di-substituted urea from the reaction solution, and further including a step of reacting the N,N?-di-substituted urea obtained in the urea produc-tion step with an organic compound containing a hydroxyl group to produce the aromatic primary amine and aromatic urethane, and separating the aromatic primary amine to produce aromatic urethane.