603-54-3

Usage

InChI:InChI=1S/C13H12N2O/c14-13(16)15(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,14,16)

Upstream product

• 24665-93-8 4,5-dihydro-oxazol-2-ylamine 
• 62-53-3 aniline 
• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 22625-57-6 5-(chloromethyl)-1,3-oxazolidin-2-one 
• 861323-42-4 5-amino-3-methylimidazolidine-2,4-dione 
• 103-71-9 phenyl isocyanate 
• 827-42-9 5-phenyl-3H-1,2-dithiol-3-one 
• 1199-02-6 5-phenyl-3H-[1,3,4]oxadiazol-2-one 
• 563-79-1 2,3-Dimethyl-2-butene 
• 1115-12-4 carbonyl cyanide 
• 2037-95-8 1,3-benzoxazine-2,4-dione 
• 2812-77-3 diethyl imidocarbonate 
• 64-17-5 ethanol 
• 142-04-1 aniline hydrochloride 

Downstream Products

• 4930-03-4 phenyl N-phenylcarbamate 
• 4456-80-8 N,N'-diphenyladipamide 
• 509-77-3 3,3-bis(4-aminophenyl)isobenzofuran-1-(3H)-one 
• 10312-53-5 3,3-bis-(4-amino-phenyl)-2,3-dihydro-isoindol-1-one 
• 6488-59-1 diphenylparabanic acid 
• 7391-60-8 1,3-diphenylbarbituric acid 
• 7474-18-2 3,3-diphenylpropanoic acid N-phenylamide 
• 587-90-6 bis-N,N'-(4-nitrophenyl)urea 
• 2908-76-1 bis(2,4-dinitrophenyl)amine 
• 6341-55-5 N,N'-bis(p-bromophenyl)urea 
• 20632-35-3 bis(2,4,6-trichlorodiphenyl)urea 
• 2788-21-8 N,N'-dichloro-N,N'-diphenyl-urea 
• 100398-93-4 diphenyl-trichlorophosphoranyliden-urea 
• 500693-57-2 N,N'-bis-(2,4-dinitro-phenyl)-urea 

Relevant academic research and scientific papers

One-pot radiosynthesis of [13N]urea and [13N] carbamate using no-carrier-added [13N]NH3

The aim of this study was to develop a practical labeling method of [ 13N]ligands using no-carrier-added [13N]NH3 with high specific activity. [13N]urea analogues [13N]1a and [13N]2a or [13N]carbamate [13N]3a were synthesized by reacting isocyanate 5a, carbamoyl chloride 6a or chloroformate 7a with [13N]NH3. The precursors 5a-7a were prepared by treating amines 8a and 9a and alcohol 10a with triphosgene in situ. These reaction mixtures were not purified and were used directly for [ 13N]ammonolysis, respectively. Using the one-pot method, we synthesized [13N]carbamazepine ([13N]4), a putative positron emission tomography ligand for brain imaging. Copyright

Process for preparing n,n'-disubstituted urea using selenium-based catalyst

A process is disclosed for preparing N,N'-disubstituted urea by reacting an amine and CO/O2 mixture gas in the presence of a catalyst system comprising at least one selenium compound selected from SeO2, (CH3O)Se(O)(OH) and (CH3CH2O)Se(O)(OH), and M2CO3 (M=alkali metal) as a co-catalyst. The process enables less active aromatic amine with a low reactivity as well as an aliphatic amine to be easily transformed into disubstituted urea avoiding the use of expensive precious metal catalysts.

Novel alpha-cyano-beta-oxopropionamides

α-(Substituted carbamoyl)-β-aryl- and heteroaryl-β-oxo-propionitriles of formula, , A-CO- enol ethers thereof and salts thereof, as well as pharmaceutical preparations containing same and methods of preparing and using these compounds are disclosed. Said compounds represent novel antiinflammatory and antirheumatic agents. Their property to interfere with both the cyclooxygenase and lipoxygenase pathway of the arachidonic fatty acid bioconversion to inflammatory mediators make them valuable therapeutics. These properties render the mentioned substituted carbamoyl-β-oxopropionitriles useful for the treatment of arthritic and rheumatic diseases and other inflammatory conditions in mammals.

Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents

Certain trisubstituted alkyl, aryl, pyridinyl, piperidinyl, and piperazinyl urea compounds stimulate the release of acetylcholine and are thus useful agents for the treatment of senile cognitive decline characterized by decreased cerebral acetylcholine production or release. A method for treating the symptoms of senile cognitive decline is disclosed.

Method of manufacturing aromatic urethane

This invention is a method of manufacturing aro-matic urethane including an aromatic urea production step of reacting an aromatic primary amine, an aromatic nitro-compound, and carbon monoxide with one another, using a catalyst mainly consisting of a compound con-taining a platinum group metal, and using a compound having a coordination ability to the catalyst as at least part of a solvent, thereby producing N,N?-di--substituted urea, and separating and isolating the produced N,N?-di-substituted urea from the reaction solution, and further including a step of reacting the N,N?-di-substituted urea obtained in the urea produc-tion step with an organic compound containing a hydroxyl group to produce the aromatic primary amine and aromatic urethane, and separating the aromatic primary amine to produce aromatic urethane.

Process for preparing an acyl-lactam compound

The invention relates to a process for preparing an acyl-lactam compound characterized in that the reaction product of a lactam with a dicarboxylic acid anhydride is reacted with a polyol at a temperature of 150° C. at most. These acyl-lactam compounds are very suitable as activator in the preparation of nylon block copolymers, more specifically in the RIM or RRIM systems.

Muramyldipeptide derivatives

Muramyldipeptide derivatives represented by the formula: STR1 wherein Ala represents alanine; Acyl represents an acyl group; R1 and R2 each represents a hydrogen atom or, when taken together, may form an alkylidene group; R3 represents a hydrogen atom, an acyl group or an alkyl group; and R4 represents a hydrogen atom or an alkyl group. These compounds have excellent immunoadjuvant activity, prophylactic and therapeutic effects against microbial infections, and antitumor activity.

Preparation of isocyanates and/or derivatives thereof

Isocyanates and derivatives thereof are prepared by oxidative conversion of compounds having at least one group STR1 wherein X represents OY or STR2 wherein Y is H, a metal ion or group NR3 R4 R5 R6 wherein each of R3, R4, R5 and R6 which may be the same or different, is H, alkyl or (substituted) (alk)aryl and Z is a (substituted) alkyl or aryl group. Phenyl isocyanate and derivatives thereof are preferably prepared electrochemically from the corresponding oxamides and oxanilides.

An efficient synthesis of 1,1-disubstituted hydrazines

1,1-disubstituted hydrazines were prepared from the corresponding 1,1-disubstituted ureas by means of the Hofmann rearrangement reaction. The yields were fairly good, except from the ureas susceptible to oxidation, and thus the present method represents an additional and efficient procedure for the synthesis of 1,1-disubstituted hydrazines.

Process for the production of N,O-disubstituted urethanes and use thereof as starting materials for the production of organic isocyanates

The present invention is directed to a process for the production of N,O-disubstituted urethanes comprising reacting N-mono- or N,N'-disubstituted ureas or linear polyureas with aliphatic carbonic esters.