52613-19-1Relevant articles and documents
In vivo evaluation and atom-based 3D-QSAR studies on saponins from shells of Xanthoceras sorbifolium Bunge as anti-AD agents
Chen, Gang,Cheng, Maosheng,Li, Ning,Liu, Yang,Xie, Yumeng,Yang, Lei,Zhou, Di,Zou, Libo
, (2019/12/24)
A series of oleanane type of glycosides (1–19), including nine undescribed ones (1–9), were isolated and identified from Xanthoceras sorbifolium. Subsequently, an atom-based 3D-QSAR model was constructed based on results of the in vivo anti-AD evaluation of the isolates (2–3, 10–17) and nine literature-reported anti-AD oleanane type of glycosides to clarify the structure-anti-AD activity, and under the guidance of which 19 was predicted and proved to elicit a nearly equivalent in vivo anti-AD effect as xanthoceraside and donepezil that were used as positive drugs in the Y maze and Morris water maze test.
N-glycosylated carboxylic acid derivatives as agents for combating rheumatic diseases
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, (2008/06/13)
A method of combating rheumatic diseases which comprises administering to a patient afflicted therewith an amount effective to combat such disease of a compound of the formula STR1 in which Z is a glycosyl radical bonded via the anomeric carbon atom, Rsu
Antihypertensive pyridazin(2H)-3-ones
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, (2008/06/13)
Compounds of the formula STR1 are useful antihypertensive agents.
